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Gene: PRSS12 (serine protease 12) Homo sapiens
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Symbol: PRSS12
Name: serine protease 12
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in exocytosis and zymogen activation. Predicted to localize to several cellular components, including the dendrite; synaptic cleft; and terminal bouton. Implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: brain-specific serine protease 3; BSSP-3; BSSP3; leydin; MGC12722; motopsin; MRT1; neurotrypsin; protease, serine 12; protease, serine, 12 (neurotrypsin, motopsin)
Orthologs:
Mus musculus (house mouse) : Prss12 (protease, serine 12 neurotrypsin (motopsin))  MGI  Alliance
Rattus norvegicus (Norway rat) : Prss12 (serine protease 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prss12 (serine protease 12)
Pan paniscus (bonobo/pygmy chimpanzee) : PRSS12 (serine protease 12)
Canis lupus familiaris (dog) : PRSS12 (serine protease 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prss12 (serine protease 12)
Sus scrofa (pig) : PRSS12 (serine protease 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384118,280,038 - 118,353,042 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374119,201,193 - 119,274,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364119,421,865 - 119,493,370 (-)NCBINCBI36hg18NCBI36
Build 344119,560,019 - 119,631,525NCBI
Celera4116,492,317 - 116,565,055 (-)NCBI
Cytogenetic Map4q26NCBI
HuRef4114,936,619 - 115,009,040 (-)NCBIHuRef
CHM1_14119,177,431 - 119,250,161 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PRSS12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733403
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.