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Gene: PRSS12 (serine protease 12) Homo sapiens
Symbol: PRSS12
Name: serine protease 12
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in exocytosis and zymogen activation. Predicted to localize to several cellular components, including the dendrite; synaptic cleft; and terminal bouton. Implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: brain-specific serine protease 3; BSSP-3; BSSP3; leydin; MGC12722; motopsin; MRT1; neurotrypsin; protease, serine 12; protease, serine, 12 (neurotrypsin, motopsin)
Mus musculus (house mouse) : Prss12 (protease, serine 12 neurotrypsin (motopsin))  MGI  Alliance
Rattus norvegicus (Norway rat) : Prss12 (serine protease 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prss12 (serine protease 12)
Pan paniscus (bonobo/pygmy chimpanzee) : PRSS12 (serine protease 12)
Canis lupus familiaris (dog) : PRSS12 (serine protease 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prss12 (serine protease 12)
Sus scrofa (pig) : PRSS12 (serine protease 12)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384118,280,038 - 118,353,042 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374119,201,193 - 119,274,053 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364119,421,865 - 119,493,370 (-)NCBINCBI36hg18NCBI36
Build 344119,560,019 - 119,631,525NCBI
Celera4116,492,317 - 116,565,055 (-)NCBI
Cytogenetic Map4q26NCBI
HuRef4114,936,619 - 115,009,040 (-)NCBIHuRef
CHM1_14119,177,431 - 119,250,161 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PRSS12
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733403
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.