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Gene: Aptx (aprataxin) Mus musculus
Symbol: Aptx
Name: aprataxin
Description: Exhibits DNA 5'-adenosine monophosphate hydrolase activity. Involved in DNA ligation and single strand break repair. Predicted to colocalize with the nuclear chromatin. Human ortholog(s) of this gene implicated in ataxia with oculomotor apraxia type 1 and olivopontocerebellar atrophy. Orthologous to human APTX (aprataxin); PARTICIPATES IN non-homologous end joining pathway of double-strand break repair; INTERACTS WITH 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2410016G21Rik; AA388047; FHA-HIT; forkhead-associated domain histidine triad-like protein; forkhead-associated domain histidine-triad like
Homo sapiens (human) : APTX (aprataxin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Aptx (aprataxin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aptx (aprataxin)
Pan paniscus (bonobo/pygmy chimpanzee) : APTX (aprataxin)
Canis lupus familiaris (dog) : APTX (aprataxin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aptx (aprataxin)
Sus scrofa (pig) : APTX (aprataxin)
Chlorocebus sabaeus (African green monkey) : APTX (aprataxin)
Heterocephalus glaber (naked mole-rat) : Aptx (aprataxin)
more info ...
Related Pseudogenes: Gm14741  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl440,682,382 - 40,703,194 (-)EnsemblGRCm38mm10GRCm38
GRCm38440,682,078 - 40,721,667 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37440,629,111 - 40,650,220 (-)NCBIGRCm37mm9NCBIm37
MGSCv36440,871,049 - 40,891,858 (-)NCBImm8
Celera440,342,394 - 40,363,460 (-)NCBICelera
Cytogenetic Map4A5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Aptx
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733411
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.