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Gene: Pcx (pyruvate carboxylase) Mus musculus
Symbol: Pcx
Name: pyruvate carboxylase
Description: Predicted to have anion binding activity; identical protein binding activity; and pyruvate carboxylase activity. Predicted to be involved in several processes, including carboxylic acid metabolic process; gluconeogenesis; and positive regulation by host of viral release from host cell. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PC (pyruvate carboxylase); PARTICIPATES IN alanine metabolic pathway; citric acid cycle pathway; fructose-1,6-bisphosphatase deficiency pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 1H-pyrazole.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Pc; Pcb; pyruvate carboxylase, mitochondrial; pyruvate decarboxylase; pyruvic carboxylase
Homo sapiens (human) : PC (pyruvate carboxylase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pc (pyruvate carboxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pc (pyruvate carboxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : PC (pyruvate carboxylase)
Canis lupus familiaris (dog) : PC (pyruvate carboxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pc (pyruvate carboxylase)
Sus scrofa (pig) : PC (pyruvate carboxylase)
Chlorocebus sabaeus (green monkey) : PC (pyruvate carboxylase)
Heterocephalus glaber (naked mole-rat) : Pc (pyruvate carboxylase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl194,510,472 - 4,621,752 (+)Ensembl
GRCm38194,510,472 - 4,621,752 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37194,510,472 - 4,621,752 (+)NCBIGRCm37mm9NCBIm37
MGSCv36194,594,346 - 4,621,698 (+)NCBImm8
Celera194,381,239 - 4,492,934 (+)NCBICelera
Cytogenetic Map19 ANCBI
cM Map194.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pcx
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733419
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-01-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.