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Gene: BECN1 (beclin 1) Homo sapiens
Symbol: BECN1
Name: beclin 1
Description: Exhibits enzyme binding activity and phosphatidylinositol 3-kinase binding activity. Involved in several processes, including early endosome to late endosome transport; mitophagy; and regulation of cell cycle process. Localizes to the endoplasmic reticulum; endosome; and extrinsic component of membrane. Colocalizes with the mitochondrion. Implicated in Machado-Joseph disease. Biomarker of several diseases, including Barrett's esophagus; adenocarcinoma (multiple); neurodegenerative disease (multiple); osteoarthritis; and perinatal necrotizing enterocolitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ATG6; ATG6 autophagy related 6 homolog; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin 1 (coiled-coil, myosin-like bcl2-interacting protein); beclin 1, autophagy related; beclin-1; beclin1; coiled-coil myosin-like BCL2-interacting protein; testis secretory sperm-binding protein Li 215e; VPS30
Mus musculus (house mouse) : Becn1 (beclin 1, autophagy related)  MGI  Alliance
Rattus norvegicus (Norway rat) : Becn1 (beclin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Becn1 (beclin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : BECN1 (beclin 1)
Canis lupus familiaris (dog) : BECN1 (beclin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Becn1 (beclin 1)
Sus scrofa (pig) : BECN1 (beclin 1)
more info ...
Related Pseudogenes: BECN1P2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1742,810,134 - 42,833,350 (-)Ensembl
GRCh381742,810,132 - 42,824,316 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,962,150 - 40,976,310 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361738,215,678 - 38,229,807 (-)NCBINCBI36hg18NCBI36
Build 341738,215,677 - 38,229,807NCBI
Celera1737,618,135 - 37,632,364 (-)NCBI
Cytogenetic Map17q21.31NCBI
HuRef1736,726,539 - 36,740,774 (-)NCBIHuRef
CHM1_11741,197,767 - 41,211,946 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on BECN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733440
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.