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Gene: Tpcn1 (two pore channel 1) Mus musculus
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Symbol: Tpcn1
Name: two pore channel 1
Description: Exhibits phosphatidylinositol-3,5-bisphosphate binding activity; protein homodimerization activity; and sodium channel activity. Involved in sodium ion transmembrane transport. Localizes to integral component of membrane. Is expressed in several structures, including brain; genitourinary system; great vessel of heart; heart; and hemolymphoid system gland. Orthologous to human TPCN1 (two pore segment channel 1); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 5730403B01Rik; mKIAA1169; Tpc1; two pore calcium channel protein 1; voltage-dependent calcium channel protein TPC1
Orthologs:
Homo sapiens (human) : TPCN1 (two pore segment channel 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tpcn1 (two pore segment channel 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tpcn1 (two pore segment channel 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TPCN1 (two pore segment channel 1)
Canis lupus familiaris (dog) : TPCN1 (two pore segment channel 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tpcn1 (two pore segment channel 1)
Sus scrofa (pig) : TPCN1 (two pore segment channel 1)
Chlorocebus sabaeus (African green monkey) : TPCN1 (two pore segment channel 1)
Heterocephalus glaber (naked mole-rat) : Tpcn1 (two pore segment channel 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl5120,534,153 - 120,588,673 (-)EnsemblGRCm38mm10GRCm38
GRCm385120,534,157 - 120,588,678 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375120,984,166 - 121,038,622 (-)NCBIGRCm37mm9NCBIm37
MGSCv365120,794,774 - 120,849,230 (-)NCBImm8
Celera5117,618,746 - 117,673,755 (-)NCBICelera
Cytogenetic Map5FNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tpcn1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733444
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.