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Gene: NFYA (nuclear transcription factor Y subunit alpha) Homo sapiens
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Symbol: NFYA
Name: nuclear transcription factor Y subunit alpha
Description: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein subunit A; CBF-A; CBF-B; CCAAT-binding transcription factor subunit B; FLJ11236; HAP2; HAP2 CCAAT-binding protein; NF-YA; nuclear transcription factor Y subunit A; nuclear transcription factor Y, alpha; nuclear transcription factor-y alpha; Transcription factor NF-Y, A subunit
Orthologs:
Mus musculus (house mouse) : Nfya (nuclear transcription factor-Y alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfya (nuclear transcription factor Y subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfya (nuclear transcription factor Y subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : NFYA (nuclear transcription factor Y subunit alpha)
Canis lupus familiaris (dog) : NFYA (nuclear transcription factor Y subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfya (nuclear transcription factor Y subunit alpha)
Sus scrofa (pig) : NFYA (nuclear transcription factor Y subunit alpha)
more info ...
Related Pseudogenes: NFYAP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38641,072,968 - 41,102,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,040,707 - 41,070,146 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,148,688 - 41,174,713 (+)NCBINCBI36hg18NCBI36
Build 34641,148,687 - 41,174,714NCBI
Celera642,593,388 - 42,622,828 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef640,758,459 - 40,787,895 (+)NCBIHuRef
CHM1_1641,043,210 - 41,072,650 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NFYA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733450
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.