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Gene: NFYA (nuclear transcription factor Y subunit alpha) Homo sapiens
Symbol: NFYA
Name: nuclear transcription factor Y subunit alpha
Description: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CAAT box DNA-binding protein subunit A; CAAT-box DNA binding protein subunit A; CBF-A; CBF-B; CCAAT-binding transcription factor subunit B; FLJ11236; HAP2; HAP2 CCAAT-binding protein; NF-YA; nuclear transcription factor Y subunit A; nuclear transcription factor Y, alpha; nuclear transcription factor-y alpha; Transcription factor NF-Y, A subunit
Mus musculus (house mouse) : Nfya (nuclear transcription factor-Y alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfya (nuclear transcription factor Y subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfya (nuclear transcription factor Y subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : NFYA (nuclear transcription factor Y subunit alpha)
Canis lupus familiaris (dog) : NFYA (nuclear transcription factor Y subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfya (nuclear transcription factor Y subunit alpha)
Sus scrofa (pig) : NFYA (nuclear transcription factor Y subunit alpha)
more info ...
Related Pseudogenes: NFYAP1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38641,072,968 - 41,102,407 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37641,040,707 - 41,070,146 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36641,148,688 - 41,174,713 (+)NCBINCBI36hg18NCBI36
Build 34641,148,687 - 41,174,714NCBI
Celera642,593,388 - 42,622,828 (+)NCBI
Cytogenetic Map6p21.1NCBI
HuRef640,758,459 - 40,787,895 (+)NCBIHuRef
CHM1_1641,043,210 - 41,072,650 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NFYA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733450
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.