Gene: ATP6AP1 (ATPase H+ transporting accessory protein 1) Homo sapiens
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Symbol: ATP6AP1
Name: ATPase H+ transporting accessory protein 1
Description: This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 16A; Ac45; ATP6IP1; ATP6S1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal interacting protein 1; CF2; H-ATPase subunit; MGC129781; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; V-type proton ATPase subunit S1; vacuolar proton pump subunit S1; VATPS1; XAP-3; XAP3
Orthologs:
Mus musculus (house mouse) : Atp6ap1 (ATPase, H+ transporting, lysosomal accessory protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atp6ap1 (ATPase H+ transporting accessory protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp6ap1 (ATPase H+ transporting accessory protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP6AP1 (ATPase H+ transporting accessory protein 1)
Canis lupus familiaris (dog) : ATP6AP1 (ATPase H+ transporting accessory protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp6ap1 (ATPase H+ transporting accessory protein 1)
Sus scrofa (pig) : ATP6AP1 (ATPase H+ transporting accessory protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X154,428,632 - 154,436,517 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,656,978 - 153,664,862 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,310,172 - 153,318,056 (+)NCBINCBI36hg18NCBI36
Build 34X153,177,867 - 153,183,641NCBI
CeleraX153,818,024 - 153,825,908 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,234,564 - 142,269,596 (+)NCBIHuRef
CHM1_1X153,568,616 - 153,576,501 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ATP6AP1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733467
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-05-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.