Gene: ATP6AP1 (ATPase H+ transporting accessory protein 1) Homo sapiens
Symbol: ATP6AP1
Name: ATPase H+ transporting accessory protein 1
Description: This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 16A; Ac45; ATP6IP1; ATP6S1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal interacting protein 1; CF2; H-ATPase subunit; MGC129781; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit S1; V-type proton ATPase subunit S1; vacuolar proton pump subunit S1; VATPS1; XAP-3; XAP3
Mus musculus (house mouse) : Atp6ap1 (ATPase, H+ transporting, lysosomal accessory protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Atp6ap1 (ATPase H+ transporting accessory protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atp6ap1 (ATPase H+ transporting accessory protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ATP6AP1 (ATPase H+ transporting accessory protein 1)
Canis lupus familiaris (dog) : ATP6AP1 (ATPase H+ transporting accessory protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atp6ap1 (ATPase H+ transporting accessory protein 1)
Sus scrofa (pig) : ATP6AP1 (ATPase H+ transporting accessory protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X154,428,632 - 154,436,517 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,656,978 - 153,664,862 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,310,172 - 153,318,056 (+)NCBINCBI36hg18NCBI36
Build 34X153,177,867 - 153,183,641NCBI
CeleraX153,818,024 - 153,825,908 (+)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,234,564 - 142,269,596 (+)NCBIHuRef
CHM1_1X153,568,616 - 153,576,501 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ATP6AP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733467
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-05-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.