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Gene: IRS1 (insulin receptor substrate 1) Homo sapiens
Symbol: IRS1
Name: insulin receptor substrate 1
Description: Exhibits several functions, including SH3/SH2 adaptor activity; phosphotyrosine residue binding activity; and signaling receptor binding activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of small molecule metabolic process; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to the caveola; cytosol; and nucleoplasm. Implicated in Alzheimer's disease; coronary artery disease; and type 2 diabetes mellitus. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HIRS-1; IRS-1
Mus musculus (house mouse) : Irs1 (insulin receptor substrate 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Irs1 (insulin receptor substrate 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Irs1 (insulin receptor substrate 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IRS1 (insulin receptor substrate 1)
Canis lupus familiaris (dog) : IRS1 (insulin receptor substrate 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Irs1 (insulin receptor substrate 1)
Sus scrofa (pig) : IRS1 (insulin receptor substrate 1)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   BW376_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382226,731,317 - 226,798,790 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372227,596,033 - 227,664,545 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362227,308,182 - 227,372,719 (-)NCBINCBI36hg18NCBI36
Build 342227,425,442 - 227,489,980NCBI
Celera2221,365,560 - 221,433,036 (-)NCBI
Cytogenetic Map2q36.3NCBI
HuRef2219,439,592 - 219,507,082 (-)NCBIHuRef
CHM1_12227,601,926 - 227,669,382 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on IRS1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733473
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.