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Gene: FLT4 (fms related receptor tyrosine kinase 4) Homo sapiens
Symbol: FLT4
Name: fms related receptor tyrosine kinase 4
Description: Exhibits several functions, including VEGF-C-activated receptor activity; protein homodimerization activity; and protein phosphatase binding activity. Involved in several processes, including positive regulation of intracellular signal transduction; protein phosphorylation; and transmembrane receptor protein tyrosine kinase signaling pathway. Localizes to nucleoplasm; plasma membrane; and receptor complex. Implicated in hereditary lymphedema IA. Biomarker of lymphangioma and systemic scleroderma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CHTD7; Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4; FLT-4; FLT41; fms related tyrosine kinase 4; fms-like tyrosine kinase 4; fms-related tyrosine kinase 4; LMPH1A; LMPHM1; PCL; primary congenital lymphedema; soluble VEGFR3 variant 1; soluble VEGFR3 variant 2; soluble VEGFR3 variant 3; tyrosine-protein kinase receptor FLT4; vascular endothelial growth factor receptor 3; VEGF receptor-3; VEGFR-3; VEGFR3
Mus musculus (house mouse) : Flt4 (FMS-like tyrosine kinase 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Flt4 (Fms related receptor tyrosine kinase 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt4 (fms related receptor tyrosine kinase 4)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT4 (fms related receptor tyrosine kinase 4)
Canis lupus familiaris (dog) : FLT4 (fms related receptor tyrosine kinase 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt4 (fms related receptor tyrosine kinase 4)
Sus scrofa (pig) : FLT4 (fms related receptor tyrosine kinase 4)
Chlorocebus sabaeus (African green monkey) : FLT4 (fms related receptor tyrosine kinase 4)
Heterocephalus glaber (naked mole-rat) : Flt4 (fms related receptor tyrosine kinase 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl5180,601,506 - 180,649,624 (-)EnsemblGRCh38hg38GRCh38
GRCh385180,601,506 - 180,650,298 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375180,028,506 - 180,076,624 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365179,961,112 - 180,009,206 (-)NCBINCBI36hg18NCBI36
Build 345179,962,147 - 180,009,171NCBI
Celera5175,651,089 - 175,699,841 (-)NCBI
Cytogenetic Map5q35.3NCBI
HuRef5174,752,484 - 174,782,989 (-)NCBIHuRef
CHM1_15179,460,942 - 179,509,118 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FLT4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733488
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.