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Gene: Gpnmb (glycoprotein (transmembrane) nmb) Mus musculus
Symbol: Gpnmb
Name: glycoprotein (transmembrane) nmb
Description: Exhibits heparin binding activity and integrin binding activity. Involved in several processes, including negative regulation of tumor necrosis factor production; positive regulation of ERK1 and ERK2 cascade; and regulation of tissue remodeling. Localizes to the cytoplasmic vesicle and integral component of plasma membrane. Used to study pigment dispersion syndrome. Human ortholog(s) of this gene implicated in primary cutaneous amyloidosis. Is expressed in several structures, including alimentary system; brain; eye; heart ventricle; and mesenchyme derived from neural crest. Orthologous to human GPNMB (glycoprotein nmb); INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DC-HIL; Dchil; dendritic cell-associated heparin sulfate proteoglycan-dependent integrin ligand; dendritic cell-associated transmembrane protein; ipd; iris pigment dispersion; osteoactivin; transmembrane glycoprotein NMB
Homo sapiens (human) : GPNMB (glycoprotein nmb)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Gpnmb (glycoprotein nmb)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpnmb (glycoprotein nmb)
Pan paniscus (bonobo/pygmy chimpanzee) : GPNMB (glycoprotein nmb)
Canis lupus familiaris (dog) : GPNMB (glycoprotein nmb)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpnmb (glycoprotein nmb)
Sus scrofa (pig) : GPNMB (glycoprotein nmb)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38649,036,518 - 49,058,182 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37648,986,517 - 49,008,181 (+)NCBIGRCm37mm9NCBIm37
MGSCv36648,966,211 - 48,987,694 (+)NCBImm8
Celera649,546,153 - 49,567,869 (+)NCBICelera
Cytogenetic Map6 B2.3NCBI
cM Map623.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Gpnmb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733525
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.