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Gene: P2ry12 (purinergic receptor P2Y, G-protein coupled 12) Mus musculus
Symbol: P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Description: Exhibits ADP receptor activity and G protein-coupled adenosine receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Localizes to the cell body membrane and cell projection membrane. Predicted to colocalize with the mitochondrion. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ticlopidine pharmacodynamics pathway; INTERACTS WITH (R)-adrenaline; 1,1-dichloroethene; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900079B22Rik; 4921504D23Rik; P2Y purinoceptor 12; P2Y12
Homo sapiens (human) : P2RY12 (purinergic receptor P2Y12)  HGNC  Alliance
Rattus norvegicus (Norway rat) : P2ry12 (purinergic receptor P2Y12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2ry12 (purinergic receptor P2Y12)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RY12 (purinergic receptor P2Y12)
Canis lupus familiaris (dog) : P2RY12 (purinergic receptor P2Y12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2ry12 (purinergic receptor P2Y12)
Sus scrofa (pig) : P2RY12 (purinergic receptor P2Y12)
Chlorocebus sabaeus (African green monkey) : P2RY12 (purinergic receptor P2Y12)
Heterocephalus glaber (naked mole-rat) : P2ry12 (purinergic receptor P2Y12)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl359,216,272 - 59,262,871 (-)Ensembl
GRCm38359,216,271 - 59,262,985 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37359,020,193 - 59,066,753 (-)NCBIGRCm37mm9NCBIm37
MGSCv36359,304,201 - 59,350,751 (-)NCBImm8
Celera358,903,452 - 58,949,752 (-)NCBICelera
Cytogenetic Map3 DNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on P2ry12
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733568
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.