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Gene: P2ry12 (purinergic receptor P2Y, G-protein coupled 12) Mus musculus
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Symbol: P2ry12
Name: purinergic receptor P2Y, G-protein coupled 12
Description: Exhibits ADP receptor activity and G protein-coupled adenosine receptor activity. Involved in several processes, including cellular response to ATP; regulation of microglial cell migration; and substrate-dependent cell migration, cell extension. Localizes to the cell body membrane and cell projection membrane. Predicted to colocalize with the mitochondrion. Used to study platelet-type bleeding disorder 8. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12); PARTICIPATES IN clopidogrel pharmacodynamics pathway; clopidogrel pharmacokinetics pathway; ticlopidine pharmacodynamics pathway; INTERACTS WITH (R)-adrenaline; 1,1-dichloroethene; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900079B22Rik; 4921504D23Rik; P2Y purinoceptor 12; P2Y12
Orthologs:
Homo sapiens (human) : P2RY12 (purinergic receptor P2Y12)  HGNC  Alliance
Rattus norvegicus (Norway rat) : P2ry12 (purinergic receptor P2Y12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P2ry12 (purinergic receptor P2Y12)
Pan paniscus (bonobo/pygmy chimpanzee) : P2RY12 (purinergic receptor P2Y12)
Canis lupus familiaris (dog) : P2RY12 (purinergic receptor P2Y12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P2ry12 (purinergic receptor P2Y12)
Sus scrofa (pig) : P2RY12 (purinergic receptor P2Y12)
Chlorocebus sabaeus (African green monkey) : P2RY12 (purinergic receptor P2Y12)
Heterocephalus glaber (naked mole-rat) : P2ry12 (purinergic receptor P2Y12)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl359,216,272 - 59,262,871 (-)Ensembl
GRCm38359,216,271 - 59,262,985 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37359,020,193 - 59,066,753 (-)NCBIGRCm37mm9NCBIm37
MGSCv36359,304,201 - 59,350,751 (-)NCBImm8
Celera358,903,452 - 58,949,752 (-)NCBICelera
Cytogenetic Map3 DNCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on P2ry12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733568
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.