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Gene: DNM1L (dynamin 1 like) Homo sapiens
Symbol: DNM1L
Name: dynamin 1 like
Description: Exhibits several functions, including GTP-dependent protein binding activity; enzyme binding activity; and protein homodimerization activity. Involved in several processes, including apoptotic mitochondrial changes; dynamin family protein polymerization involved in mitochondrial fission; and regulation of mitochondrion organization. Localizes to several cellular components, including the microtubule; mitochondrial outer membrane; and perinuclear region of cytoplasm. Colocalizes with the mitochondrion-derived vesicle. Implicated in brain disease and optic atrophy. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DLP1; Dnm1p/Vps1p-like protein; DRP1; DVLP; DYMPLE; dynamin 1-like; dynamin family member proline-rich carboxyl-terminal domain less; dynamin-1-like protein; dynamin-like protein 4; dynamin-like protein IV; dynamin-related protein 1; DYNIV-11; EMPF; EMPF1; FLJ41912; HDYNIV; OPA5; VPS1
Mus musculus (house mouse) : Dnm1l (dynamin 1-like)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dnm1l (dynamin 1-like)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dnm1l (dynamin 1 like)
Pan paniscus (bonobo/pygmy chimpanzee) : DNM1L (dynamin 1 like)
Canis lupus familiaris (dog) : DNM1L (dynamin 1 like)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dnm1l (dynamin 1 like)
Sus scrofa (pig) : DNM1L (dynamin 1 like)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1232,679,200 - 32,745,650 (+)Ensembl
GRCh381232,679,200 - 32,745,650 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371232,832,134 - 32,898,584 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361232,723,491 - 32,788,621 (+)NCBINCBI36hg18NCBI36
Build 341232,723,490 - 32,787,810NCBI
Celera1212,653,086 - 12,719,281 (+)NCBI
Cytogenetic Map12p11.21NCBI
HuRef1232,584,423 - 32,651,060 (+)NCBIHuRef
CHM1_11232,798,646 - 32,865,086 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on DNM1L
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733618
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.