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Gene: HGS (hepatocyte growth factor-regulated tyrosine kinase substrate) Homo sapiens
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Symbol: HGS
Name: hepatocyte growth factor-regulated tyrosine kinase substrate
Description: Exhibits protein domain specific binding activity and ubiquitin-like protein ligase binding activity. Involved in several processes, including positive regulation of exosomal secretion; protein targeting to lysosome; and regulation of signal transduction. Localizes to the cytosol; endosome; and lysosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ11421; FLJ39878; hgf-regulated tyrosine kinase substrate; HRS; human growth factor-regulated tyrosine kinase substrate; protein pp110; Vps27; ZFYVE8
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl1781,683,326 - 81,703,138 (+)Ensembl
GRCh381781,684,011 - 81,702,121 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371779,650,962 - 79,669,151 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361777,261,425 - 77,279,553 (+)NCBINCBI36hg18NCBI36
Build 341777,261,424 - 77,279,550NCBI
Celera1776,295,942 - 76,314,294 (+)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1775,097,132 - 75,115,050 (+)NCBIHuRef
CHM1_11779,737,183 - 79,755,370 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on HGS
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733649
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.