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Gene: Ush2a (usherin) Mus musculus
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Symbol: Ush2a
Name: usherin
Description: Exhibits collagen binding activity; identical protein binding activity; and myosin binding activity. Involved in establishment of protein localization; neuron differentiation; and photoreceptor cell maintenance. Localizes to several cellular components, including the USH2 complex; periciliary membrane compartment; and stereocilia ankle link complex. Predicted to colocalize with the neuronal cell body and terminal bouton. Used to study Usher syndrome type 2A. Human ortholog(s) of this gene implicated in Usher syndrome (multiple); nonsyndromic deafness; and retinitis pigmentosa (multiple). Is expressed in sensory organ and testis. Orthologous to human USH2A (usherin); PARTICIPATES IN auditory mechanotransduction pathway; retinitis pigmentosa pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene; methamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A930011D15Rik; A930037M10Rik; Gm676; Gm983; Mush2a; Usher syndrome 2A; Usher syndrome 2A (autosomal recessive, mild); Usher syndrome 2A (autosomal recessive, mild) homolog; usher syndrome type IIa protein homolog; usher syndrome type-2A protein homolog; Ushrn
Orthologs:
Homo sapiens (human) : USH2A (usherin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ush2a (usherin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ush2a (usherin)
Pan paniscus (bonobo/pygmy chimpanzee) : USH2A (usherin)
Canis lupus familiaris (dog) : USH2A (usherin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ush2a (usherin)
Sus scrofa (pig) : USH2A (usherin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381188,262,838 - 188,965,497 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371190,086,717 - 190,788,920 (+)NCBIGRCm37mm9NCBIm37
MGSCv361189,963,822 - 190,665,716 (+)NCBImm8
Celera1195,189,439 - 195,876,703 (+)NCBICelera
Cytogenetic Map1 H6NCBI
cM Map192.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Ush2a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733684
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.