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Gene: HYAL2 (hyaluronidase 2) Homo sapiens
Symbol: HYAL2
Name: hyaluronidase 2
CRRD ID: 733698
Description: Exhibits several functions, including hyaluronic acid binding activity; hydrolase activity, hydrolyzing O-glycosyl compounds; and receptor signaling protein tyrosine kinase inhibitor activity. Predicted to contribute to transcription coactivator activity. Involved in several processes, including cellular response to growth factor stimulus; negative regulation of protein kinase activity; and positive regulation of cytokine production. Localizes to several cellular components, including anchored component of external side of plasma membrane; apical plasma membrane; and microvillus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: hyal-2; hyaluronidase-2; hyaluronoglucosaminidase 2; hyaluronoglucosaminidase-2; LuCa-2; LUCA2; lung carcinoma protein 2; lysosomal hyaluronidase; PH-20 homolog; PH20 homolog
Mus musculus (house mouse) : Hyal2 (hyaluronoglucosaminidase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hyal2 (hyaluronidase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hyal2 (hyaluronidase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : HYAL2 (hyaluronidase 2)
Canis lupus familiaris (dog) : HYAL2 (hyaluronidase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hyal2 (hyaluronidase 2)
Sus scrofa (pig) : HYAL2 (hyaluronidase 2)
Chlorocebus sabaeus (African green monkey) : HYAL2 (hyaluronidase 2)
Heterocephalus glaber (naked mole-rat) : Hyal2 (hyaluronidase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl350,317,790 - 50,322,782 (-)EnsemblGRCh38hg38GRCh38
GRCh38350,317,802 - 50,322,768 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,355,221 - 50,360,281 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,330,244 - 50,335,146 (-)NCBINCBI36hg18NCBI36
Build 34350,330,243 - 50,333,903NCBI
Celera350,328,056 - 50,333,116 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,410,935 - 50,415,994 (-)NCBIHuRef
CHM1_1350,307,488 - 50,312,547 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on HYAL2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733698
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.