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Gene: F2RL1 (F2R like trypsin receptor 1) Homo sapiens
Symbol: F2RL1
Name: F2R like trypsin receptor 1
Description: Exhibits G protein-coupled receptor activity. Involved in several processes, including cytokine secretion; regulation of cytokine secretion; and regulation of signal transduction. Localizes to early endosome and integral component of plasma membrane. Implicated in asthma; chronic obstructive pulmonary disease; and respiratory allergy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: coagulation factor II (thrombin) receptor-like 1; coagulation factor II receptor-like 1; G protein-coupled receptor-11; G-protein coupled receptor 11; GPR11; PAR-2; PAR2; protease-activated receptor 2; proteinase-activated receptor 2; proteinase-activated receptor-2; proteinase-activated receptor-2, g protein-coupled receptor 11; thrombin receptor-like 1
Mus musculus (house mouse) : F2rl1 (coagulation factor II (thrombin) receptor-like 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : F2rl1 (F2R like trypsin receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : F2rl1 (F2R like trypsin receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : F2RL1 (F2R like trypsin receptor 1)
Canis lupus familiaris (dog) : F2RL1 (F2R like trypsin receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : F2rl1 (F2R like trypsin receptor 1)
Sus scrofa (pig) : F2RL1 (F2R like trypsin receptor 1)
Chlorocebus sabaeus (African green monkey) : F2RL1 (F2R like trypsin receptor 1)
Heterocephalus glaber (naked mole-rat) : F2rl1 (F2R like trypsin receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl576,818,933 - 76,835,315 (+)EnsemblGRCh38hg38GRCh38
GRCh38576,819,030 - 76,835,315 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37576,114,833 - 76,131,140 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36576,150,610 - 76,166,896 (+)NCBINCBI36hg18NCBI36
Build 34576,150,609 - 76,166,895NCBI
Celera572,008,729 - 72,025,166 (+)NCBI
Cytogenetic Map5q13.3NCBI
HuRef571,322,693 - 71,339,004 (+)NCBIHuRef
CHM1_1575,547,934 - 75,564,299 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on F2RL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733704
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.