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Gene: CTNNB1 (catenin beta 1) Homo sapiens
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Symbol: CTNNB1
Name: catenin beta 1
Description: Exhibits several functions, including I-SMAD binding activity; enzyme binding activity; and transcription factor binding activity. Involved in several processes, including regulation of apoptotic process; regulation of cell cycle process; and regulation of cellular macromolecule biosynthetic process. Localizes to several cellular components, including the beta-catenin destruction complex; catenin complex; and nucleus. Implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); medulloblastoma; and pilomatrixoma. Biomarker of several diseases, including carcinoma (multiple); germ cell cancer (multiple); hepatoblastoma; invasive lobular carcinoma; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: armadillo; beta-catenin; catenin (cadherin-associated protein), beta 1; catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1; CTNNB; DKFZp686D02253; EVR7; FLJ25606; FLJ37923; MRD19; NEDSDV
Orthologs:
Mus musculus (house mouse) : Ctnnb1 (catenin (cadherin associated protein), beta 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ctnnb1 (catenin beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ctnnb1 (catenin beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CTNNB1 (catenin beta 1)
Canis lupus familiaris (dog) : CTNNB1 (catenin beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ctnnb1 (catenin beta 1)
Sus scrofa (pig) : CTNNB1 (catenin beta 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38341,199,422 - 41,240,445 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37341,236,401 - 41,281,939 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36341,215,946 - 41,256,943 (+)NCBINCBI36hg18NCBI36
Build 34341,216,015 - 41,256,938NCBI
Celera341,179,363 - 41,220,269 (+)NCBI
Cytogenetic Map3p22.1NCBI
HuRef341,285,983 - 41,326,988 (+)NCBIHuRef
CHM1_1341,191,513 - 41,232,505 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations