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Gene: SLC22A5 (solute carrier family 22 member 5) Homo sapiens
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Symbol: SLC22A5
Name: solute carrier family 22 member 5
Description: Exhibits PDZ domain binding activity and carnitine transmembrane transporter activity. Involved in organic cation transport; positive regulation of intestinal epithelial structure maintenance; and quorum sensing involved in interaction with host. Localizes to the apical plasma membrane and brush border membrane. Implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; and systemic primary carnitine deficiency disease. Biomarker of myelodysplastic syndrome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDSP; FLJ46769; high-affinity sodium dependent carnitine cotransporter; high-affinity sodium-dependent carnitine cotransporter; OCTN2; OCTN2VT; organic cation transporter 2; organic cation transporter 5; organic cation/carnitine transporter 2; solute carrier family 22 (organic cation transporter), member 5; solute carrier family 22 (organic cation/carnitine transporter), member 5; solute carrier family 22, member 5
Orthologs:
Mus musculus (house mouse) : Slc22a5 (solute carrier family 22 (organic cation transporter), member 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc22a5 (solute carrier family 22 member 5)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : SLC22A5 (solute carrier family 22 member 5)
Canis lupus familiaris (dog) : SLC22A5 (solute carrier family 22 member 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc22a5 (solute carrier family 22 member 5)
Sus scrofa (pig) : SLC22A5 (solute carrier family 22 member 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl5132,369,752 - 132,395,614 (+)Ensembl
GRCh385132,369,704 - 132,395,614 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375131,705,396 - 131,731,306 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,733,343 - 131,759,205 (+)NCBINCBI36hg18NCBI36
Build 345131,733,342 - 131,759,202NCBI
Celera5127,835,468 - 127,861,380 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5126,897,648 - 126,923,551 (+)NCBIHuRef
CHM1_15131,138,142 - 131,164,051 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC22A5
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733710
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.