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Gene: Atf4 (activating transcription factor 4) Mus musculus
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Symbol: Atf4
Name: activating transcription factor 4
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II distal enhancer sequence-specific DNA binding activity; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including PERK-mediated unfolded protein response; positive regulation of apoptotic process; and regulation of gene expression. Localizes to the ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; and cytoplasm. Predicted to colocalize with the centrosome. Human ortholog(s) of this gene implicated in prostate carcinoma. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and limb. Orthologous to human ATF4 (activating transcription factor 4); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Endoplasmic Reticulum-associated degradation pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (R)-lipoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Atf-4; C/ATF; c/EBP-related ATF; cAMP-dependent transcription factor ATF-4; CREB2; cyclic AMP-dependent transcription factor ATF-4; MGC96460; tax-responsive enhancer element-binding protein 67 homolog; TAXREB67; taxREB67 homolog
Orthologs:
Homo sapiens (human) : ATF4 (activating transcription factor 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Atf4 (activating transcription factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atf4 (activating transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ATF4 (activating transcription factor 4)
Canis lupus familiaris (dog) : ATF4 (activating transcription factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atf4 (activating transcription factor 4)
Sus scrofa (pig) : ATF4 (activating transcription factor 4)
Chlorocebus sabaeus (African green monkey) : ATF4 (activating transcription factor 4)
Heterocephalus glaber (naked mole-rat) : Atf4 (activating transcription factor 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1580,255,184 - 80,257,541 (+)Ensembl
GRCm381580,255,184 - 80,257,545 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371580,085,614 - 80,087,971 (+)NCBIGRCm37mm9NCBIm37
MGSCv361580,082,756 - 80,084,759 (+)NCBImm8
Celera1582,372,526 - 82,374,887 (+)NCBICelera
Cytogenetic Map15 E1NCBI
cM Map1537.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Atf4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733713
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.