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Gene: Atf4 (activating transcription factor 4) Mus musculus
Symbol: Atf4
Name: activating transcription factor 4
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II distal enhancer sequence-specific DNA binding activity; and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific. Involved in several processes, including PERK-mediated unfolded protein response; positive regulation of apoptotic process; and regulation of gene expression. Localizes to the ATF1-ATF4 transcription factor complex; ATF4-CREB1 transcription factor complex; and cytoplasm. Predicted to colocalize with the centrosome. Human ortholog(s) of this gene implicated in prostate carcinoma. Is expressed in several structures, including central nervous system; embryo ectoderm; eye; genitourinary system; and limb. Orthologous to human ATF4 (activating transcription factor 4); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Endoplasmic Reticulum-associated degradation pathway; gonadotropin-releasing hormone signaling pathway; INTERACTS WITH (R)-lipoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,4-dithiothreitol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Atf-4; C/ATF; c/EBP-related ATF; cAMP-dependent transcription factor ATF-4; CREB2; cyclic AMP-dependent transcription factor ATF-4; MGC96460; tax-responsive enhancer element-binding protein 67 homolog; TAXREB67; taxREB67 homolog
Homo sapiens (human) : ATF4 (activating transcription factor 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Atf4 (activating transcription factor 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Atf4 (activating transcription factor 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ATF4 (activating transcription factor 4)
Canis lupus familiaris (dog) : ATF4 (activating transcription factor 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Atf4 (activating transcription factor 4)
Sus scrofa (pig) : ATF4 (activating transcription factor 4)
Chlorocebus sabaeus (African green monkey) : ATF4 (activating transcription factor 4)
Heterocephalus glaber (naked mole-rat) : Atf4 (activating transcription factor 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1580,255,184 - 80,257,541 (+)Ensembl
GRCm381580,255,184 - 80,257,545 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371580,085,614 - 80,087,971 (+)NCBIGRCm37mm9NCBIm37
MGSCv361580,082,756 - 80,084,759 (+)NCBImm8
Celera1582,372,526 - 82,374,887 (+)NCBICelera
Cytogenetic Map15 E1NCBI
cM Map1537.85NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Atf4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733713
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.