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Gene: Hmgcl (3-hydroxy-3-methylglutaryl-Coenzyme A lyase) Mus musculus
Symbol: Hmgcl
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase
Description: Predicted to have several functions, including anion binding activity; hydroxymethylglutaryl-CoA lyase activity; and metal ion binding activity. Involved in mitochondrion organization. Localizes to the mitochondrion. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Is expressed in alimentary system; cranium; and liver. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase); PARTICIPATES IN 3-hydroxy-3-methylglutaryl-CoA lyase deficiency pathway; 3-hydroxyisobutyric aciduria pathway; 3-methylcrotonyl CoA carboxylase 1 deficiency pathway; INTERACTS WITH (+)-dexrazoxane; 1,1-dichloroethene; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3-hydroxy-3-methylglutarate-CoA lyase; AW476067; HL; HMG-CoA lyase; hydroxymethylglutaryl-CoA lyase, mitochondrial
Homo sapiens (human) : HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)
Pan paniscus (bonobo/pygmy chimpanzee) : HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)
Canis lupus familiaris (dog) : HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hmgcl (3-hydroxy-3-methylglutaryl-CoA lyase)
Sus scrofa (pig) : HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm384135,946,448 - 135,962,668 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374135,502,368 - 135,518,532 (+)NCBIGRCm37mm9NCBIm37
MGSCv364135,218,521 - 135,234,689 (+)NCBImm8
Celera4134,147,609 - 134,163,748 (+)NCBICelera
Cytogenetic Map4 D3NCBI
cM Map468.14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hmgcl
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733717
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.