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Gene: Mlh1 (mutL homolog 1) Mus musculus
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Symbol: Mlh1
Name: mutL homolog 1
CRRD ID: 733730
Description: Exhibits chromatin binding activity and guanine/thymine mispair binding activity. Predicted to contribute to MutSalpha complex binding activity and single-stranded DNA binding activity. Involved in several processes, including meiotic nuclear division; nucleic acid metabolic process; and regulation of DNA recombination. Localizes to nucleus. Is expressed in genitourinary system. Used to study Lynch syndrome. Human ortholog(s) of this gene implicated in Lynch syndrome; Muir-Torre syndrome; colorectal cancer; hereditary nonpolyposis colorectal cancer type 2; and sporadic breast cancer. Orthologous to human MLH1 (mutL homolog 1); PARTICIPATES IN altered mismatch repair pathway; colorectal cancer pathway; endometrial cancer pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110035C23Rik; AI317206; AI325952; AI561766; colon cancer, nonpolyposis type 2; DNA mismatch repair protein Mlh1; mutL protein homolog 1
Orthologs:
Homo sapiens (human) : MLH1 (mutL homolog 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mlh1 (mutL homolog 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mlh1 (mutL homolog 1)
Pan paniscus (bonobo/pygmy chimpanzee) : MLH1 (mutL homolog 1)
Canis lupus familiaris (dog) : MLH1 (mutL homolog 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mlh1 (mutL homolog 1)
Sus scrofa (pig) : MLH1 (mutL homolog 1)
Chlorocebus sabaeus (African green monkey) : MLH1 (mutL homolog 1)
Heterocephalus glaber (naked mole-rat) : Mlh1 (mutL homolog 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl9111,228,228 - 111,271,791 (-)EnsemblGRCm38mm10GRCm38
GRCm389111,228,228 - 111,271,786 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379111,130,732 - 111,174,112 (-)NCBIGRCm37mm9NCBIm37
MGSCv369111,073,071 - 111,116,378 (-)NCBImm8
Celera9110,951,307 - 110,994,774 (-)NCBICelera
Cytogenetic Map9F3NCBI
cM Map960.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations