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Gene: Rock1 (Rho-associated coiled-coil containing protein kinase 1) Mus musculus
Symbol: Rock1
Name: Rho-associated coiled-coil containing protein kinase 1
Description: Predicted to have GTP-Rho binding activity; Rho-dependent protein serine/threonine kinase activity; and aspartic-type endopeptidase inhibitor activity. Involved in several processes, including bleb assembly; mRNA destabilization; and positive regulation of focal adhesion assembly. Localizes to several cellular components, including the cytoplasmic stress granule; lamellipodium; and ruffle. Predicted to colocalize with the amyloid-beta complex. Is expressed in several structures, including brain; diaphragm; gut; heart; and musculature. Orthologous to human ROCK1 (Rho associated coiled-coil containing protein kinase 1); PARTICIPATES IN E-cadherin signaling pathway; eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine; 4-vinylcyclohexene dioxide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110055K06Rik; p160 ROCK-1; p160ROCK; Rho-associated coiled-coil forming kinase 1; rho-associated protein kinase 1; rho-associated, coiled-coil-containing protein kinase 1; rho-associated, coiled-coil-containing protein kinase I; Rock-I
Related Pseudogenes: Gm5374  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1810,064,401 - 10,182,045 (-)Ensembl
GRCm381810,064,401 - 10,182,251 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371810,064,399 - 10,181,790 (-)NCBIGRCm37mm9NCBIm37
MGSCv361810,067,465 - 10,181,315 (-)NCBImm8
Celera1810,094,528 - 10,211,725 (-)NCBICelera
Cytogenetic Map18 A1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Rock1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733752
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.