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Gene: NPR2 (natriuretic peptide receptor 2) Homo sapiens
Symbol: NPR2
Name: natriuretic peptide receptor 2
Description: Exhibits guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Involved in cGMP biosynthetic process; cellular response to granulocyte macrophage colony-stimulating factor stimulus; and receptor guanylyl cyclase signaling pathway. Localizes to the integral component of plasma membrane. Implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acromesomelic dysplasia, Maroteaux type; AMDM; ANP-B; ANPb; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor type B; ECDM; GC-B; guanylate cyclase 2B; guanylate cyclase B; GUC2B; GUCY2B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); NPR-B; NPRB; NPRBi; SNSK
Mus musculus (house mouse) : Npr2 (natriuretic peptide receptor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Npr2 (natriuretic peptide receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr2 (natriuretic peptide receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR2 (natriuretic peptide receptor 2)
Canis lupus familiaris (dog) : NPR2 (natriuretic peptide receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr2 (natriuretic peptide receptor 2)
Sus scrofa (pig) : NPR2 (natriuretic peptide receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38935,782,086 - 35,809,731 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37935,789,962 - 35,809,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,782,406 - 35,799,728 (+)NCBINCBI36hg18NCBI36
Build 34935,782,405 - 35,799,709NCBI
Celera935,725,947 - 35,743,260 (+)NCBI
Cytogenetic Map9p13.3NCBI
HuRef935,748,436 - 35,765,752 (+)NCBIHuRef
CHM1_1935,792,795 - 35,810,116 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NPR2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733765
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.