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Gene: NPR2 (natriuretic peptide receptor 2) Homo sapiens
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Symbol: NPR2
Name: natriuretic peptide receptor 2
Description: Exhibits guanylate cyclase activity; natriuretic peptide receptor activity; and peptide hormone binding activity. Involved in cGMP biosynthetic process; cellular response to granulocyte macrophage colony-stimulating factor stimulus; and receptor guanylyl cyclase signaling pathway. Localizes to the integral component of plasma membrane. Implicated in Miura type epiphyseal chondrodysplasia; acromesomelic dysplasia, Maroteaux type; and essential hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acromesomelic dysplasia, Maroteaux type; AMDM; ANP-B; ANPb; ANPR-B; ANPRB; atrial natriuretic peptide B-type receptor; atrial natriuretic peptide receptor 2; atrial natriuretic peptide receptor type B; ECDM; GC-B; guanylate cyclase 2B; guanylate cyclase B; GUC2B; GUCY2B; natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B); NPR-B; NPRB; NPRBi; SNSK
Orthologs:
Mus musculus (house mouse) : Npr2 (natriuretic peptide receptor 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Npr2 (natriuretic peptide receptor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr2 (natriuretic peptide receptor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR2 (natriuretic peptide receptor 2)
Canis lupus familiaris (dog) : NPR2 (natriuretic peptide receptor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr2 (natriuretic peptide receptor 2)
Sus scrofa (pig) : NPR2 (natriuretic peptide receptor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38935,782,086 - 35,809,731 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37935,789,962 - 35,809,728 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36935,782,406 - 35,799,728 (+)NCBINCBI36hg18NCBI36
Build 34935,782,405 - 35,799,709NCBI
Celera935,725,947 - 35,743,260 (+)NCBI
Cytogenetic Map9p13.3NCBI
HuRef935,748,436 - 35,765,752 (+)NCBIHuRef
CHM1_1935,792,795 - 35,810,116 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NPR2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733765
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.