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Gene: CBLB (Cbl proto-oncogene B) Homo sapiens
Symbol: CBLB
Name: Cbl proto-oncogene B
CRRD ID: 733798
Description: Predicted to have SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Predicted to be involved in several processes, including positive regulation of T cell anergy; regulation of protein metabolic process; and regulation of signal transduction. Localizes to cytosol and nucleoplasm. Implicated in type 1 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Cas-Br-M (murine) ectropic retroviral transforming sequence b; casitas B-lineage lymphoma proto-oncogene b; Cbl proto-oncogene B, E3 ubiquitin protein ligase; Cbl proto-oncogene, E3 ubiquitin protein ligase B; Cbl-b; DKFZp686J10223; DKFZp779A0729; DKFZp779F1443; E3 ubiquitin-protein ligase CBL-B; FLJ36865; FLJ41152; Nbla00127; RING finger protein 56; RING-type E3 ubiquitin transferase CBL-B; RNF56; SH3-binding protein CBL-B; signal transduction protein CBL-B
Mus musculus (house mouse) : Cblb (Casitas B-lineage lymphoma b)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cblb (Cbl proto-oncogene B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cblb (Cbl proto-oncogene B)
Pan paniscus (bonobo/pygmy chimpanzee) : CBLB (Cbl proto-oncogene B)
Canis lupus familiaris (dog) : CBLB (Cbl proto-oncogene B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cblb (Cbl proto-oncogene B)
Sus scrofa (pig) : CBLB (Cbl proto-oncogene B)
Chlorocebus sabaeus (African green monkey) : CBLB (Cbl proto-oncogene B)
Heterocephalus glaber (naked mole-rat) : Cblb (Cbl proto-oncogene B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3105,655,461 - 105,869,552 (-)EnsemblGRCh38hg38GRCh38
GRCh383105,655,461 - 105,869,552 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373105,374,306 - 105,589,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363106,859,799 - 107,070,577 (-)NCBINCBI36hg18NCBI36
Build 343106,859,798 - 107,070,577NCBI
Celera3103,775,519 - 103,986,437 (-)NCBI
Cytogenetic Map3q13.11NCBI
HuRef3102,751,829 - 102,962,841 (-)NCBIHuRef
CHM1_13105,337,423 - 105,551,745 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CBLB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733798
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.