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Gene: Cblb (Casitas B-lineage lymphoma b) Mus musculus
Symbol: Cblb
Name: Casitas B-lineage lymphoma b
CRRD ID: 733799
Description: Predicted to have SH3 domain binding activity; receptor tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including positive regulation of T cell anergy; positive regulation of protein metabolic process; and regulation of signal transduction. Predicted to localize to several cellular components, including cytosol; membrane raft; and nucleoplasm. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B); PARTICIPATES IN chronic myeloid leukemia pathway; endocytosis pathway; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; arsenite(3-).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI429560; AI851073; casitas B-lineage lymphoma proto-oncogene b; Cbl-; Cbl-b; E3 ubiquitin-protein ligase CBL-B; RING-type E3 ubiquitin transferase CBL-B; SH3-binding protein CBL-B; signal transduction protein CBL-B
Homo sapiens (human) : CBLB (Cbl proto-oncogene B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cblb (Cbl proto-oncogene B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cblb (Cbl proto-oncogene B)
Pan paniscus (bonobo/pygmy chimpanzee) : CBLB (Cbl proto-oncogene B)
Canis lupus familiaris (dog) : CBLB (Cbl proto-oncogene B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cblb (Cbl proto-oncogene B)
Sus scrofa (pig) : CBLB (Cbl proto-oncogene B)
Chlorocebus sabaeus (African green monkey) : CBLB (Cbl proto-oncogene B)
Heterocephalus glaber (naked mole-rat) : Cblb (Cbl proto-oncogene B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391651,851,593 - 52,028,410 (+)NCBI
GRCm381652,031,230 - 52,208,047 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1652,031,225 - 52,208,048 (+)EnsemblGRCm38mm10GRCm38
MGSCv371652,031,662 - 52,208,160 (+)NCBIGRCm37mm9NCBIm37
MGSCv361651,950,573 - 52,127,397 (+)NCBImm8
Celera1652,360,484 - 52,539,724 (+)NCBICelera
Cytogenetic Map16B5NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cblb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733799
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.