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Gene: NFIB (nuclear factor I B) Homo sapiens
Symbol: NFIB
Name: nuclear factor I B
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II proximal promoter sequence-specific DNA binding activity; and transcription corepressor activity. Involved in brain development; negative regulation of DNA binding activity; and regulation of transcription by RNA polymerase II. Localizes to the fibrillar center and nucleoplasm; PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 17beta-estradiol; 17beta-hydroxy-5alpha-androstan-3-one; 2-hydroxypropanoic acid.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CCAAT-box-binding transcription factor; CTF; HMGIC/NFIB; MACID; NF-I/B; NF1-B; NFI-B; NFI-RED; NFIB2; NFIB3; nuclear factor 1 B-type; nuclear factor 1/B; nuclear factor I/B; TGGCA-binding protein
Mus musculus (house mouse) : Nfib (nuclear factor I/B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nfib (nuclear factor I/B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nfib (nuclear factor I B)
Pan paniscus (bonobo/pygmy chimpanzee) : NFIB (nuclear factor I B)
Canis lupus familiaris (dog) : NFIB (nuclear factor I B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nfib (nuclear factor I B)
Sus scrofa (pig) : NFIB (nuclear factor I B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38914,081,843 - 14,532,077 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37914,081,842 - 14,398,982 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36914,071,847 - 14,303,945 (-)NCBINCBI36hg18NCBI36
Build 34914,077,372 - 14,303,719NCBI
Celera914,015,384 - 14,332,471 (-)NCBI
Cytogenetic Map9p23-p22.3NCBI
HuRef914,045,221 - 14,362,372 (-)NCBIHuRef
CHM1_1914,081,962 - 14,399,030 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NFIB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733820
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.