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Gene: GSK3B (glycogen synthase kinase 3 beta) Homo sapiens
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Symbol: GSK3B
Name: glycogen synthase kinase 3 beta
Description: Exhibits several functions, including enzyme binding activity; protein kinase activity; and transcription factor binding activity. Involved in several processes, including pallium development; protein phosphorylation; and regulation of neuron death. Localizes to several cellular components, including beta-catenin destruction complex; centrosome; and glutamatergic synapse. Implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Biomarker of colorectal adenocarcinoma; degenerative disc disease; endometrial carcinoma; and schizophrenia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: glycogen synthase kinase-3 beta; GSK-3 beta; GSK3beta isoform; serine/threonine-protein kinase GSK3B
Orthologs:
Mus musculus (house mouse) : Gsk3b (glycogen synthase kinase 3 beta)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gsk3b (glycogen synthase kinase 3 beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gsk3b (glycogen synthase kinase 3 beta)
Pan paniscus (bonobo/pygmy chimpanzee) : GSK3B (glycogen synthase kinase 3 beta)
Canis lupus familiaris (dog) : GSK3B (glycogen synthase kinase 3 beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gsk3b (glycogen synthase kinase 3 beta)
Sus scrofa (pig) : GSK3B (glycogen synthase kinase 3 beta)
Chlorocebus sabaeus (African green monkey) : GSK3B (glycogen synthase kinase 3 beta)
Heterocephalus glaber (naked mole-rat) : Gsk3b (glycogen synthase kinase 3 beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3119,821,323 - 120,094,417 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl3119,821,321 - 120,094,447 (-)EnsemblGRCh38hg38GRCh38
GRCh383119,821,321 - 120,095,823 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373119,540,800 - 119,813,264 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363121,028,233 - 121,295,203 (-)NCBINCBI36hg18NCBI36
Build 343121,028,237 - 121,295,203NCBI
Celera3117,949,905 - 118,223,017 (-)NCBI
Cytogenetic Map3q13.33NCBI
HuRef3116,916,542 - 117,189,344 (-)NCBIHuRef
CHM1_13119,504,331 - 119,776,722 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


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RNA-SEQ Expression

Sequence

Nucleotide Sequences