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Gene: TH (tyrosine hydroxylase) Homo sapiens
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Symbol: TH
Name: tyrosine hydroxylase
Description: Exhibits enzyme binding activity and tyrosine 3-monooxygenase activity. Involved in catecholamine biosynthetic process; response to ethanol; and response to hypoxia. Localizes to several cellular components, including the cytoplasmic side of plasma membrane; melanosome membrane; and smooth endoplasmic reticulum. Implicated in Parkinson's disease; hypertension; and obesity. Biomarker of Parkinson's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dystonia 14; DYT14; DYT5b; TYH; tyrosine 3-hydroxylase; tyrosine 3-monooxygenase
Orthologs:
Mus musculus (house mouse) : Th (tyrosine hydroxylase)  MGI  Alliance
Rattus norvegicus (Norway rat) : Th (tyrosine hydroxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Th (tyrosine hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : TH (tyrosine hydroxylase)
Canis lupus familiaris (dog) : TH (tyrosine hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Th (tyrosine hydroxylase)
Sus scrofa (pig) : TH (tyrosine hydroxylase)
Chlorocebus sabaeus (green monkey) : TH (tyrosine hydroxylase)
Heterocephalus glaber (naked mole-rat) : Th (tyrosine hydroxylase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl112,163,929 - 2,171,877 (-)Ensembl
GRCh38112,163,929 - 2,174,081 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,185,159 - 2,193,107 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,141,735 - 2,149,611 (-)NCBINCBI36hg18NCBI36
Build 34112,141,735 - 2,149,605NCBI
Celera112,221,752 - 2,229,624 (-)NCBI
Cytogenetic Map11p15.5NCBI
HuRef111,975,424 - 1,983,299 (-)NCBIHuRef
CHM1_1112,183,941 - 2,191,817 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on TH
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733897
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.