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Gene: RAD50 (RAD50 double strand break repair protein) Homo sapiens
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Symbol: RAD50
Name: RAD50 double strand break repair protein
Description: Exhibits DNA binding activity; identical protein binding activity; and protein binding activity, bridging. Contributes to 3'-5' exonuclease activity; DNA helicase activity; and single-stranded DNA endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; positive regulation of phosphorylation; and regulation of DNA metabolic process. Localizes to the Mre11 complex; nuclear chromosome, telomeric region; and site of double-strand break. Implicated in transitional cell carcinoma. Biomarker of invasive ductal carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNA repair protein RAD50; hRad50; NBSLD; RAD50 homolog; RAD50-2; RAD502
Orthologs:
Mus musculus (house mouse) : Rad50 (RAD50 double strand break repair protein)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rad50 (RAD50 double strand break repair protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rad50 (RAD50 double strand break repair protein)
Pan paniscus (bonobo/pygmy chimpanzee) : RAD50 (RAD50 double strand break repair protein)
Canis lupus familiaris (dog) : RAD50 (RAD50 double strand break repair protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rad50 (RAD50 double strand break repair protein)
Sus scrofa (pig) : RAD50 (RAD50 double strand break repair protein)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl5132,556,019 - 132,646,349 (+)Ensembl
GRCh385132,556,977 - 132,646,349 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375131,892,616 - 131,980,313 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,920,529 - 132,007,498 (+)NCBINCBI36hg18NCBI36
Build 345131,920,528 - 132,007,492NCBI
Celera5128,022,732 - 128,110,444 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5127,084,875 - 127,172,627 (+)NCBIHuRef
CHM1_15131,325,888 - 131,413,608 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model