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Gene: ELOC (elongin C) Homo sapiens
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Symbol: ELOC
Name: elongin C
Description: This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: elongation factor siii p15 subunit; elongin 15 kDa subunit; elongin-C; RNA polymerase II transcription factor SIII subunit C; SIII; SIII p15; TCEB1; transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C); transcription elongation factor B polypeptide 1; transcription elongation factor B subunit 1; transcription elongation factor B, polypeptide 1
Orthologs:
Mus musculus (house mouse) : Eloc (elongin C)  MGI  Alliance
Rattus norvegicus (Norway rat) : Eloc (elongin C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eloc (elongin C)
Pan paniscus (bonobo/pygmy chimpanzee) : ELOC (elongin C)
Canis lupus familiaris (dog) : ELOC (elongin C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eloc (elongin C)
Sus scrofa (pig) : ELOC (elongin C)
more info ...
Related Pseudogenes: ELOCP10   ELOCP11   ELOCP12   ELOCP13   ELOCP14   ELOCP15   ELOCP16   ELOCP17   ELOCP18   ELOCP19   ELOCP2   ELOCP20   ELOCP21   ELOCP22   ELOCP23   ELOCP24   ELOCP26   ELOCP27   ELOCP28   ELOCP29   ELOCP3   ELOCP30   ELOCP31   ELOCP32   ELOCP34   ELOCP35   ELOCP4   ELOCP5   ELOCP6   ELOCP7   ELOCP8   ELOCP9  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38873,945,119 - 73,972,287 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37874,857,373 - 74,884,522 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36875,021,188 - 75,046,900 (-)NCBINCBI36hg18NCBI36
Build 34875,021,187 - 75,046,900NCBI
Celera870,856,322 - 70,882,037 (-)NCBI
Cytogenetic Map8q21.11NCBI
HuRef870,348,271 - 70,375,431 (-)NCBIHuRef
CHM1_1874,909,297 - 74,936,449 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ELOC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733902
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.