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Gene: TIMP2 (TIMP metallopeptidase inhibitor 2) Homo sapiens
Symbol: TIMP2
Name: TIMP metallopeptidase inhibitor 2
Description: This gene is a member of the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix. In addition to an inhibitory role against metalloproteinases, the encoded protein has a unique role among TIMP family members in its ability to directly suppress the proliferation of endothelial cells. As a result, the encoded protein may be critical to the maintenance of tissue homeostasis by suppressing the proliferation of quiescent tissues in response to angiogenic factors, and by inhibiting protease activity in tissues undergoing remodelling of the extracellular matrix. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CSC-21K; DDC8; KIAA1731NL; metalloproteinase inhibitor 2; testicular secretory protein Li 57; TIMP-2; tissue inhibitor of metalloproteinase 2; tissue inhibitor of metalloproteinases 2
Mus musculus (house mouse) : Timp2 (tissue inhibitor of metalloproteinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Timp2 (TIMP metallopeptidase inhibitor 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Timp2 (TIMP metallopeptidase inhibitor 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Canis lupus familiaris (dog) : TIMP2 (TIMP metallopeptidase inhibitor 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Timp2 (TIMP metallopeptidase inhibitor 2)
Sus scrofa (pig) : TIMP2 (TIMP metallopeptidase inhibitor 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381778,852,977 - 78,925,387 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371776,849,059 - 76,921,472 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361774,360,654 - 74,433,067 (-)NCBINCBI36hg18NCBI36
Build 341774,360,655 - 74,433,067NCBI
Celera1773,446,776 - 73,467,725 (-)NCBI
Cytogenetic Map17q25.3NCBI
HuRef1772,271,475 - 72,343,528 (-)NCBIHuRef
CHM1_11776,912,998 - 76,985,403 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on TIMP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733906
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.