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Gene: NAE1 (NEDD8 activating enzyme E1 subunit 1) Homo sapiens
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Symbol: NAE1
Name: NEDD8 activating enzyme E1 subunit 1
Description: Exhibits protein heterodimerization activity and ubiquitin protein ligase binding activity. Contributes to NEDD8 activating enzyme activity. Involved in several processes, including mitotic DNA replication checkpoint; neuron apoptotic process; and protein neddylation. Localizes to the protein-containing complex. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A-116A10.1; amyloid beta precursor protein binding protein 1, 59kDa; amyloid beta precursor protein-binding protein 1, 59 kDa; amyloid beta precursor protein-binding protein 1, 59kD; amyloid protein-binding protein 1; app-binding protein 1; APP-BP1; APPBP1; HPP1; NEDD8-activating enzyme E1 regulatory subunit; NEDD8-activating enzyme E1 subunit; proto-oncogene protein 1; protooncogene protein 1; ula-1
Orthologs:
Mus musculus (house mouse) : Nae1 (NEDD8 activating enzyme E1 subunit 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nae1 (NEDD8 activating enzyme E1 subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nae1 (NEDD8 activating enzyme E1 subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
Canis lupus familiaris (dog) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nae1 (NEDD8 activating enzyme E1 subunit 1)
Sus scrofa (pig) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381666,802,878 - 66,830,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371666,836,781 - 66,864,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,394,282 - 65,422,380 (-)NCBINCBI36hg18NCBI36
Build 341665,394,282 - 65,422,370NCBI
Celera1651,345,091 - 51,373,189 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1652,710,930 - 52,739,089 (-)NCBIHuRef
CHM1_11668,243,864 - 68,271,962 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on NAE1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733941
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.