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Gene: NAE1 (NEDD8 activating enzyme E1 subunit 1) Homo sapiens
Symbol: NAE1
Name: NEDD8 activating enzyme E1 subunit 1
Description: Exhibits protein heterodimerization activity and ubiquitin protein ligase binding activity. Contributes to NEDD8 activating enzyme activity. Involved in several processes, including mitotic DNA replication checkpoint; neuron apoptotic process; and protein neddylation. Localizes to the protein-containing complex. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: A-116A10.1; amyloid beta precursor protein binding protein 1, 59kDa; amyloid beta precursor protein-binding protein 1, 59 kDa; amyloid beta precursor protein-binding protein 1, 59kD; amyloid protein-binding protein 1; app-binding protein 1; APP-BP1; APPBP1; HPP1; NEDD8-activating enzyme E1 regulatory subunit; NEDD8-activating enzyme E1 subunit; proto-oncogene protein 1; protooncogene protein 1; ula-1
Mus musculus (house mouse) : Nae1 (NEDD8 activating enzyme E1 subunit 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nae1 (NEDD8 activating enzyme E1 subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nae1 (NEDD8 activating enzyme E1 subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
Canis lupus familiaris (dog) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nae1 (NEDD8 activating enzyme E1 subunit 1)
Sus scrofa (pig) : NAE1 (NEDD8 activating enzyme E1 subunit 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381666,802,878 - 66,830,977 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371666,836,781 - 66,864,880 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361665,394,282 - 65,422,380 (-)NCBINCBI36hg18NCBI36
Build 341665,394,282 - 65,422,370NCBI
Celera1651,345,091 - 51,373,189 (-)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1652,710,930 - 52,739,089 (-)NCBIHuRef
CHM1_11668,243,864 - 68,271,962 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on NAE1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733941
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.