17alpha-ethynylestradiol affects expression EXP 6480464 Ethinyl Estradiol affects the expression of CUL5 mRNA CTD PMID:17555576 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of CUL5 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of CUL5 mRNA CTD PMID:15034205 2,3,7,8-tetrachlorodibenzodioxine multiple interactions EXP 6480464 AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CUL5 mRNA] CTD PMID:15034205 2,4-dinitrotoluene affects expression ISO RGD:621742 6480464 2, 4-dinitrotoluene affects the expression of CUL5 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:733947 6480464 Lactic Acid results in decreased expression of CUL5 mRNA CTD PMID:30851411 3,4-methylenedioxymethamphetamine increases methylation EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased methylation of CUL5 promoter CTD PMID:26251327 3,4-methylenedioxymethamphetamine decreases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of CUL5 mRNA CTD PMID:26251327 3,4-methylenedioxymethamphetamine increases expression EXP 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of CUL5 mRNA CTD PMID:26251327 5-fluorouracil increases expression ISO RGD:733947 6480464 Fluorouracil results in increased expression of CUL5 mRNA CTD PMID:16557594 acrylamide decreases expression ISO RGD:621742 6480464 Acrylamide results in decreased expression of CUL5 mRNA CTD PMID:28959563 all-trans-retinoic acid decreases expression ISO RGD:733947 6480464 Tretinoin results in decreased expression of CUL5 mRNA CTD PMID:17045167 ammonium chloride affects expression ISO RGD:621742 6480464 Ammonium Chloride affects the expression of CUL5 mRNA CTD PMID:16483693 arsenous acid increases expression ISO RGD:733947 6480464 Arsenic Trioxide results in increased expression of CUL5 mRNA CTD PMID:17530438 bathocuproine disulfonic acid multiple interactions ISO RGD:733947 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA] CTD PMID:15477007 benzo[a]pyrene increases expression ISO RGD:733947 6480464 Benzo(a)pyrene results in increased expression of CUL5 mRNA CTD PMID:20064835 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of CUL5 mRNA CTD PMID:15034205 benzo[a]pyrene multiple interactions EXP 6480464 AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CUL5 mRNA] CTD PMID:15034205 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:733947 6480464 7 more ... CTD PMID:19150397 beta-naphthoflavone multiple interactions ISO RGD:621742 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CUL5 mRNA CTD PMID:18164116 bisphenol A decreases expression ISO RGD:733947 6480464 bisphenol A results in decreased expression of CUL5 mRNA CTD PMID:20678512 bisphenol A increases expression ISO RGD:621742 6480464 bisphenol A results in increased expression of CUL5 mRNA CTD PMID:25181051 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of CUL5 mRNA CTD PMID:21151649 desmopressin increases expression ISO RGD:621742 6480464 Deamino Arginine Vasopressin results in increased expression of CUL5 protein CTD PMID:21734099 diarsenic trioxide increases expression ISO RGD:733947 6480464 Arsenic Trioxide results in increased expression of CUL5 mRNA CTD PMID:17530438 dicrotophos decreases expression ISO RGD:733947 6480464 dicrotophos results in decreased expression of CUL5 mRNA CTD PMID:28302478 dieldrin affects expression ISO RGD:621742 6480464 Dieldrin affects the expression of CUL5 mRNA CTD PMID:22546817 dorsomorphin multiple interactions ISO RGD:733947 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CUL5 mRNA CTD PMID:27188386 doxorubicin increases expression ISO RGD:733947 6480464 Doxorubicin results in increased expression of CUL5 mRNA CTD PMID:29803840 geldanamycin increases expression ISO RGD:733947 6480464 geldanamycin results in increased expression of CUL5 mRNA CTD PMID:26705709 hypochlorous acid increases expression EXP 6480464 Hypochlorous Acid results in increased expression of CUL5 mRNA CTD PMID:19376150 ionomycin multiple interactions ISO RGD:733947 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA] more ... CTD PMID:15477007 N-nitrosodiethylamine multiple interactions ISO RGD:621742 6480464 [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CUL5 mRNA CTD PMID:18164116 paracetamol decreases expression ISO RGD:733947 6480464 Acetaminophen results in decreased expression of CUL5 mRNA CTD PMID:21420995 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of CUL5 mRNA CTD PMID:23091169 phenylmercury acetate increases expression ISO RGD:733947 6480464 Phenylmercuric Acetate results in increased expression of CUL5 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:733947 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CUL5 mRNA CTD PMID:27188386 phorbol 13-acetate 12-myristate multiple interactions ISO RGD:733947 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA] more ... CTD PMID:15477007 potassium chromate increases expression ISO RGD:733947 6480464 potassium chromate(VI) results in increased expression of CUL5 mRNA CTD PMID:22714537 pyrrolidine dithiocarbamate multiple interactions ISO RGD:733947 6480464 [bathocuproine sulfonate co-treated with pyrrolidine dithiocarbamic acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA], pyrrolidine dithiocarbamic acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of CUL5 mRNA] CTD PMID:15477007 rac-lactic acid decreases expression ISO RGD:733947 6480464 Lactic Acid results in decreased expression of CUL5 mRNA CTD PMID:30851411 resveratrol increases expression ISO RGD:733947 6480464 resveratrol results in increased expression of CUL5 protein CTD PMID:20949323 SB 431542 multiple interactions ISO RGD:733947 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CUL5 mRNA CTD PMID:27188386 sodium arsenate increases expression EXP 6480464 sodium arsenate results in increased expression of CUL5 mRNA CTD PMID:21795629 tamoxifen affects expression EXP 6480464 Tamoxifen affects the expression of CUL5 mRNA CTD PMID:17555576 testosterone enanthate affects expression ISO RGD:733947 6480464 testosterone enanthate affects the expression of CUL5 mRNA CTD PMID:17440010 thioacetamide increases expression ISO RGD:621742 6480464 Thioacetamide results in increased expression of CUL5 mRNA CTD PMID:23411599 trichostatin A affects expression ISO RGD:733947 6480464 trichostatin A affects the expression of CUL5 mRNA CTD PMID:28542535 valproic acid decreases expression ISO RGD:733947 6480464 Valproic Acid results in decreased expression of CUL5 mRNA CTD PMID:23179753 vinclozolin increases expression ISO RGD:621742 6480464 vinclozolin results in increased expression of CUL5 mRNA CTD PMID:20566332
Biological Process
cerebral cortex radially oriented cell migration IMP 2290270 (MGI:MGI:5545793, PMID:24210661) MGI MGI:MGI:5545793 , PMID:24210661 proteasome-mediated ubiquitin-dependent protein catabolic process IBA FB:FBgn0261268 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 proteasome-mediated ubiquitin-dependent protein catabolic process IBA CGD:CAL0000174561 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 protein ubiquitination IGI MGI:MGI:2651588 2290270 (MGI:MGI:5545793, PMID:24210661) MGI MGI:MGI:5545793 , PMID:24210661 radial glia guided migration of Purkinje cell IMP 2290270 (MGI:MGI:5545793, PMID:24210661) MGI MGI:MGI:5545793 , PMID:24210661 regulation of cytosolic calcium ion concentration ISO RGD:621742 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA MGI:MGI:1349658 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IBA CGD:CAL0000174561 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ubiquitin-dependent protein catabolic process IBA MGI:MGI:1914487 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ubiquitin-dependent protein catabolic process IBA MGI:MGI:1914487 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635
Cellular Component
Cul5-RING ubiquitin ligase complex ISO UniProtKB:Q93034 2290270 MGI GO_REF:0000008, MGI:MGI:2154458 Cul5-RING ubiquitin ligase complex IBA FB:FBgn0039632 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cullin-RING ubiquitin ligase complex IBA PANTHER:PTN000231993 , UniProtKB:Q13616 2290270 (PMID:21873635) GO_Central PMID:21873635 cullin-RING ubiquitin ligase complex IBA PANTHER:PTN000231993 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 cytoplasm ISO RGD:621742 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 nucleus ISO RGD:621742 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 plasma membrane ISO RGD:621742 2290270 RGD GO_REF:0000096, MGI:MGI:4417868 SCF ubiquitin ligase complex IBA FB:FBgn0015509 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 site of DNA damage ISO UniProtKB:Q93034 2290270 MGI GO_REF:0000096, MGI:MGI:4834177
Molecular Function
protein binding IPI UniProtKB:O35718 2290270 (MGI:MGI:3513692, PMID:15601820) MGI MGI:MGI:3513692 , PMID:15601820 protein binding IPI UniProtKB:Q8VHQ2 2290270 (MGI:MGI:5545793, PMID:24210661) MGI MGI:MGI:5545793 , PMID:24210661 protein binding IPI UniProtKB:E9Q9D5 2290270 (MGI:MGI:5468889, PMID:23055941) MGI MGI:MGI:5468889 , PMID:23055941 protein heterodimerization activity IPI UniProtKB:Q9JLV5 2290270 (MGI:MGI:5499695, PMID:22709582) MGI MGI:MGI:5499695 , PMID:22709582 ubiquitin protein ligase binding ISO UniProtKB:Q93034 2290270 MGI GO_REF:0000096, MGI:MGI:4834177 ubiquitin protein ligase binding IBA FB:FBgn0015509 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635 ubiquitin protein ligase binding IBA FB:FBgn0015509 more ... 2290270 (PMID:21873635) GO_Central PMID:21873635