Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PPP3CB (protein phosphatase 3 catalytic subunit beta) Homo sapiens
Analyze
Symbol: PPP3CB
Name: protein phosphatase 3 catalytic subunit beta
Description: Exhibits several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in several processes, including calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Localizes to the calcineurin complex and cytoplasm. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia; PARTICIPATES IN interleukin-12 signaling pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methylcholine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calcineurin A beta; calcineurin A2; calmodulin-dependent calcineurin A subunit beta isoform; CALNA2; CALNB; CAM-PRP catalytic subunit; CNA beta; CNA2; PP2Bbeta; protein phosphatase 2B, catalytic subunit, beta isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform; protein phosphatase 3, catalytic subunit, beta isoform; protein phosphatase from PCR fragment H32; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Orthologs:
Mus musculus (house mouse) : Ppp3cb (protein phosphatase 3, catalytic subunit, beta isoform)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
Canis lupus familiaris (dog) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)
Sus scrofa (pig) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381073,436,428 - 73,496,024 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371075,196,563 - 75,255,782 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,866,618 - 74,925,758 (-)NCBINCBI36hg18NCBI36
Build 341074,866,617 - 74,925,760NCBI
Celera1068,482,159 - 68,541,381 (-)NCBI
Cytogenetic Map10q22.2NCBI
HuRef1069,190,274 - 69,249,395 (-)NCBIHuRef
CHM1_11075,477,948 - 75,537,525 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PPP3CB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733965
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.