Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PPP3CB (protein phosphatase 3 catalytic subunit beta) Homo sapiens
Symbol: PPP3CB
Name: protein phosphatase 3 catalytic subunit beta
Description: Exhibits several functions, including calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein phosphatase 2B binding activity. Involved in several processes, including calcineurin-NFAT signaling cascade; positive regulation of transcription by RNA polymerase II; and protein dephosphorylation. Localizes to the calcineurin complex and cytoplasm. Implicated in aortic valve stenosis. Biomarker of focal segmental glomerulosclerosis and schizophrenia; PARTICIPATES IN interleukin-12 signaling pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-methylcholine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: calcineurin A beta; calcineurin A2; calmodulin-dependent calcineurin A subunit beta isoform; CALNA2; CALNB; CAM-PRP catalytic subunit; CNA beta; CNA2; PP2Bbeta; protein phosphatase 2B, catalytic subunit, beta isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform; protein phosphatase 3, catalytic subunit, beta isoform; protein phosphatase from PCR fragment H32; serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
Mus musculus (house mouse) : Ppp3cb (protein phosphatase 3, catalytic subunit, beta isoform)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
Canis lupus familiaris (dog) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppp3cb (protein phosphatase 3 catalytic subunit beta)
Sus scrofa (pig) : PPP3CB (protein phosphatase 3 catalytic subunit beta)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381073,436,428 - 73,496,024 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371075,196,563 - 75,255,782 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361074,866,618 - 74,925,758 (-)NCBINCBI36hg18NCBI36
Build 341074,866,617 - 74,925,760NCBI
Celera1068,482,159 - 68,541,381 (-)NCBI
Cytogenetic Map10q22.2NCBI
HuRef1069,190,274 - 69,249,395 (-)NCBIHuRef
CHM1_11075,477,948 - 75,537,525 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPP3CB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733965
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.