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Gene: IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta) Homo sapiens
Symbol: IKBKB
Name: inhibitor of nuclear factor kappa B kinase subunit beta
Description: Exhibits several functions, including protein dimerization activity; protein serine/threonine kinase activity; and scaffold protein binding activity. Predicted to contribute to IkappaB kinase activity. Involved in several processes, including cytokine-mediated signaling pathway; regulation of phosphate metabolic process; and regulation of transcription, DNA-templated. Localizes to the cytosol. Implicated in breast cancer; dermatitis; primary immunodeficiency disease; prostate cancer (multiple); and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ33771; FLJ36218; FLJ38368; FLJ40509; I-kappa-B kinase 2; I-kappa-B-kinase beta; IKK-B; IKK-beta; IKK2; IKKB; IMD15; IMD15A; IMD15B; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta; inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; nuclear factor NF-kappa-B inhibitor kinase beta
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38842,270,727 - 42,332,653 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37842,128,820 - 42,190,171 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36842,247,986 - 42,309,122 (+)NCBINCBI36hg18NCBI36
Build 34842,247,985 - 42,309,122NCBI
Celera841,077,798 - 41,138,835 (+)NCBI
Cytogenetic Map8p11.21NCBI
HuRef840,656,604 - 40,717,697 (+)NCBIHuRef
CHM1_1842,177,451 - 42,238,764 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IKBKB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733968
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.