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Gene: Tsc1 (TSC complex subunit 1) Mus musculus
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Symbol: Tsc1
Name: TSC complex subunit 1
CRRD ID: 733994
Description: Exhibits ATPase inhibitor activity and protein N-terminus binding activity. Involved in several processes, including animal organ development; negative regulation of cell size; and nervous system development. Localizes to cytoplasm and postsynaptic density. Predicted to colocalize with actin filament. Is expressed in several structures, including central nervous system; genitourinary system; hepatic primordium; liver; and retina. Used to study anterior segment dysgenesis; autism spectrum disorder; autosomal recessive polycystic kidney disease; and tuberous sclerosis. Human ortholog(s) of this gene implicated in intellectual disability; lymphangioleiomyomatosis; tuberous sclerosis; and tuberous sclerosis 1. Orthologous to human TSC1 (TSC complex subunit 1); PARTICIPATES IN adenosine monophosphate-activated protein kinase (AMPK) signaling pathway; mTOR signaling pathway; insulin signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ham; hamartin; mKIAA0243; tuberous sclerosis 1; tuberous sclerosis 1 protein homolog
Orthologs:
Homo sapiens (human) : TSC1 (TSC complex subunit 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tsc1 (TSC complex subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tsc1 (TSC complex subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TSC1 (TSC complex subunit 1)
Canis lupus familiaris (dog) : TSC1 (TSC complex subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tsc1 (TSC complex subunit 1)
Sus scrofa (pig) : TSC1 (TSC complex subunit 1)
Chlorocebus sabaeus (African green monkey) : TSC1 (TSC complex subunit 1)
Heterocephalus glaber (naked mole-rat) : Tsc1 (TSC complex subunit 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl228,641,228 - 28,691,167 (+)EnsemblGRCm38mm10GRCm38
GRCm38228,640,993 - 28,691,172 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37228,496,763 - 28,546,687 (+)NCBIGRCm37mm9NCBIm37
MGSCv36228,463,252 - 28,513,176 (+)NCBImm8
Celera228,345,749 - 28,395,673 (+)NCBICelera
Cytogenetic Map2A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Tsc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733994
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.