Symbol:
CDS1
Name:
CDP-diacylglycerol synthase 1
Description:
Exhibits phosphatidate cytidylyltransferase activity. Involved in CDP-diacylglycerol biosynthetic process and phosphatidylinositol biosynthetic process. Predicted to localize to the endoplasmic reticulum and endoplasmic reticulum membrane.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
CDP-DAG synthase 1; CDP-DG synthase 1; CDP-DG synthetase 1; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1; CDP-diglyceride pyrophosphorylase 1; CDP-diglyceride synthase 1; CDP-diglyceride synthetase 1; CDS; CDS 1; CTP:phosphatidate cytidylyltransferase 1; phosphatidate cytidylyltransferase 1
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Cds1 (CDP-diacylglycerol synthase 1) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Cds1 (CDP-diacylglycerol synthase 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Chinchilla lanigera (long-tailed chinchilla):
Cds1 (CDP-diacylglycerol synthase 1) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
CDS1 (CDP-diacylglycerol synthase 1) NCBI
Ortholog
Canis lupus familiaris (dog):
CDS1 (CDP-diacylglycerol synthase 1) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Cds1 (CDP-diacylglycerol synthase 1) NCBI
Ortholog
Sus scrofa (pig):
CDS1 (CDP-diacylglycerol synthase 1) HGNC
EggNOG, Ensembl, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Other homologs 2
Mus musculus (house mouse):
Cds2 (CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2) HGNC
OrthoMCL
Canis lupus familiaris (dog):
CDS2 (CDP-diacylglycerol synthase 2) HGNC
OrthoMCL
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Cds1 (CDP-diacylglycerol synthase 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Cds1 (CDP-diacylglycerol synthase 1)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
cds1 (CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1)
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER, TreeFam, ZFIN)
Saccharomyces cerevisiae (baker's yeast):
CDS1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
Cds
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
cdgs-1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PhylomeDB, Roundup, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 4 84,582,931 - 84,651,334 (+) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 4 85,504,057 - 85,572,493 (+) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 4 85,723,081 - 85,789,379 (+) NCBI NCBI36 hg18 NCBI36 Build 34 4 85,861,235 - 85,927,518 NCBI Celera 4 82,794,273 - 82,862,979 (+) NCBI Cytogenetic Map 4 q21.23 NCBI HuRef 4 81,245,783 - 81,314,483 (+) NCBI HuRef CHM1_1 4 85,481,027 - 85,549,447 (+) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
(S)-nicotine increases splicing EXP 6480464 Nicotine results in increased splicing of CDS1 mRNA alternative form CTD PMID:23825647 1,1-dichloroethene decreases expression ISO RGD:737009 6480464 vinylidene chloride results in decreased expression of CDS1 mRNA CTD PMID:26682919 17alpha-ethynylestradiol multiple interactions ISO RGD:737009 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDS1 mRNA CTD PMID:17942748 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of CDS1 mRNA CTD PMID:19167446 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:737009 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of CDS1 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737009 6480464 Tetrachlorodibenzodioxin results in increased expression of CDS1 mRNA CTD PMID:28213091 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:621185 6480464 Tetrachlorodibenzodioxin results in decreased expression of CDS1 mRNA CTD PMID:21215274 2,4-dinitrotoluene affects expression ISO RGD:621185 6480464 2, 4-dinitrotoluene affects the expression of CDS1 mRNA CTD PMID:21346803 4,4'-diaminodiphenylmethane decreases expression ISO RGD:737009 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of CDS1 mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide increases expression ISO RGD:737009 6480464 Fenretinide results in increased expression of CDS1 mRNA CTD PMID:28973697 6-propyl-2-thiouracil decreases expression ISO RGD:621185 6480464 Propylthiouracil results in decreased expression of CDS1 mRNA CTD PMID:24780913 acetylsalicylic acid increases expression ISO RGD:621185 6480464 Aspirin results in increased expression of CDS1 mRNA CTD PMID:12800193 acrylamide decreases expression ISO RGD:621185 6480464 Acrylamide results in decreased expression of CDS1 mRNA CTD PMID:28959563 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of CDS1 mRNA CTD PMID:21934132 ammonium chloride affects expression ISO RGD:621185 6480464 Ammonium Chloride affects the expression of CDS1 mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:737009 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of CDS1 mRNA CTD PMID:23650126 arsenous acid increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CDS1 mRNA CTD PMID:29633893 benzo[a]pyrene decreases expression ISO RGD:737009 6480464 Benzo(a)pyrene results in decreased expression of CDS1 mRNA CTD PMID:22228805 benzo[a]pyrene multiple interactions ISO RGD:737009 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of CDS1 mRNA] CTD PMID:22228805 bisphenol A increases expression ISO RGD:737009 6480464 bisphenol A results in increased expression of CDS1 mRNA CTD PMID:26063408 bisphenol F increases expression ISO RGD:737009 6480464 bisphenol F results in increased expression of CDS1 mRNA CTD PMID:30951980 butanal increases expression EXP 6480464 butyraldehyde results in increased expression of CDS1 mRNA CTD PMID:26079696 butyric acid increases expression ISO RGD:621185 6480464 Butyric Acid results in increased expression of CDS1 mRNA CTD PMID:12800193 calcitriol increases expression EXP 6480464 Calcitriol results in increased expression of CDS1 mRNA CTD PMID:16002434 , PMID:26485663 cobalt dichloride decreases expression ISO RGD:621185 6480464 cobaltous chloride results in decreased expression of CDS1 mRNA CTD PMID:24386269 copper atom decreases expression ISO RGD:621185 6480464 Copper deficiency results in decreased expression of CDS1 mRNA CTD PMID:19821111 copper(0) decreases expression ISO RGD:621185 6480464 Copper deficiency results in decreased expression of CDS1 mRNA CTD PMID:19821111 coumestrol decreases expression EXP 6480464 Coumestrol results in decreased expression of CDS1 mRNA CTD PMID:19167446 coumestrol multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CDS1 mRNA CTD PMID:19167446 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of CDS1 mRNA CTD PMID:27989131 diarsenic trioxide increases expression EXP 6480464 Arsenic Trioxide results in increased expression of CDS1 mRNA CTD PMID:29633893 dicrotophos decreases expression EXP 6480464 dicrotophos results in decreased expression of CDS1 mRNA CTD PMID:28302478 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin affects expression EXP 6480464 Doxorubicin affects the expression of CDS1 mRNA CTD PMID:25529476 doxorubicin decreases expression EXP 6480464 Doxorubicin results in decreased expression of CDS1 mRNA CTD PMID:29803840 elemental selenium decreases expression EXP 6480464 Selenium results in decreased expression of CDS1 mRNA CTD PMID:19244175 endosulfan increases expression ISO RGD:621185 6480464 Endosulfan results in increased expression of CDS1 mRNA CTD PMID:29391264 Enterolactone multiple interactions EXP 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of CDS1 mRNA CTD PMID:19167446 furan increases expression ISO RGD:621185 6480464 furan results in increased expression of CDS1 mRNA CTD PMID:25539665 hypochlorous acid decreases expression ISO RGD:737009 6480464 Hypochlorous Acid results in decreased expression of CDS1 mRNA CTD PMID:19376150 indole-3-methanol affects expression ISO RGD:621185 6480464 indole-3-carbinol affects the expression of CDS1 mRNA CTD PMID:21396975 iron atom decreases expression ISO RGD:621185 6480464 Iron deficiency results in decreased expression of CDS1 mRNA CTD PMID:19821111 iron(0) decreases expression ISO RGD:621185 6480464 Iron deficiency results in decreased expression of CDS1 mRNA CTD PMID:19821111 lead(0) affects expression EXP 6480464 Lead affects the expression of CDS1 mRNA CTD PMID:28903495 lead(2+) affects expression EXP 6480464 Lead affects the expression of CDS1 mRNA CTD PMID:28903495 mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of CDS1 mRNA CTD PMID:26272509 mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDS1 mRNA CTD PMID:27188386 methotrexate increases expression EXP 6480464 Methotrexate results in increased expression of CDS1 mRNA CTD PMID:24449571 N-methyl-4-phenylpyridinium increases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in increased expression of CDS1 mRNA CTD PMID:24810058 nicotine increases splicing EXP 6480464 Nicotine results in increased splicing of CDS1 mRNA alternative form CTD PMID:23825647 phenylmercury acetate increases expression EXP 6480464 Phenylmercuric Acetate results in increased expression of CDS1 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDS1 mRNA CTD PMID:27188386 pirinixic acid decreases expression ISO RGD:737009 6480464 pirinixic acid results in decreased expression of CDS1 mRNA CTD PMID:20813756 pravastatin increases expression ISO RGD:621185 6480464 Pravastatin results in increased expression of CDS1 mRNA CTD PMID:27225895 pravastatin increases expression ISO RGD:737009 6480464 Pravastatin results in increased expression of CDS1 mRNA CTD PMID:27225895 propanal increases expression EXP 6480464 propionaldehyde results in increased expression of CDS1 mRNA CTD PMID:26079696 quercetin decreases expression EXP 6480464 Quercetin results in decreased expression of CDS1 mRNA CTD PMID:21632981 rotenone increases expression ISO RGD:621185 6480464 Rotenone results in increased expression of CDS1 mRNA CTD PMID:28374803 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 selenium atom decreases expression EXP 6480464 Selenium results in decreased expression of CDS1 mRNA CTD PMID:19244175 silicon dioxide decreases expression EXP 6480464 Silicon Dioxide analog results in decreased expression of CDS1 mRNA CTD PMID:25895662 tetrachloromethane increases expression ISO RGD:621185 6480464 Carbon Tetrachloride results in increased expression of CDS1 mRNA CTD PMID:31150632 thioacetamide increases expression ISO RGD:621185 6480464 Thioacetamide results in increased expression of CDS1 mRNA CTD PMID:23411599 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of CDS1 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions EXP 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDS1 mRNA CTD PMID:27188386 triclosan increases expression EXP 6480464 Triclosan results in increased expression of CDS1 mRNA CTD PMID:30510588 valproic acid increases expression ISO RGD:737009 6480464 Valproic Acid results in increased expression of CDS1 mRNA CTD PMID:21427059 valproic acid increases expression EXP 6480464 Valproic Acid results in increased expression of CDS1 mRNA CTD PMID:23179753 more ... valproic acid multiple interactions EXP 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of CDS1 mRNA CTD PMID:27188386 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of CDS1 mRNA CTD PMID:25979313 vinclozolin decreases expression ISO RGD:621185 6480464 vinclozolin results in decreased expression of CDS1 mRNA CTD PMID:23555832 vitamin E decreases expression EXP 6480464 Vitamin E results in decreased expression of CDS1 mRNA CTD PMID:19244175 zaragozic acid A increases expression ISO RGD:621185 6480464 squalestatin 1 results in increased expression of CDS1 mRNA CTD PMID:27225895 zaragozic acid A increases expression ISO RGD:737009 6480464 squalestatin 1 results in increased expression of CDS1 mRNA CTD PMID:27225895 
Gene-Chemical Interaction Annotations
