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Gene: SHANK1 (SH3 and multiple ankyrin repeat domains 1) Homo sapiens
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Symbol: SHANK1
Name: SH3 and multiple ankyrin repeat domains 1
Description: Predicted to have several functions, including GKAP/Homer scaffold activity; protein domain specific binding activity; and signaling receptor binding activity. Involved in several processes, including determination of affect; social behavior; and vocalization behavior. Localizes to the plasma membrane. Predicted to colocalize with the NMDA selective glutamate receptor complex and postsynaptic membrane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: SH3 and multiple ankyrin repeat domains protein 1; somatostatin receptor-interacting protein; SPANK-1; SSTR-interacting protein; SSTRIP; synamon
Orthologs:
Mus musculus (house mouse) : Shank1 (SH3 and multiple ankyrin repeat domains 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Shank1 (SH3 and multiple ankyrin repeat domains 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Shank1 (SH3 and multiple ankyrin repeat domains 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
Canis lupus familiaris (dog) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Shank1 (SH3 and multiple ankyrin repeat domains 1)
Sus scrofa (pig) : SHANK1 (SH3 and multiple ankyrin repeat domains 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381950,659,255 - 50,719,802 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371951,163,052 - 51,220,195 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361955,856,896 - 55,912,007 (-)NCBINCBI36hg18NCBI36
Build 341955,856,895 - 55,912,007NCBI
Celera1948,216,374 - 48,271,323 (-)NCBI
Cytogenetic Map19q13.33NCBI
HuRef1947,499,910 - 47,555,290 (-)NCBIHuRef
CHM1_11951,164,298 - 51,221,938 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on SHANK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734100
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.