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Gene: Nr1h4 (nuclear receptor subfamily 1, group H, member 4) Mus musculus
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Symbol: Nr1h4
Name: nuclear receptor subfamily 1, group H, member 4
Description: Exhibits bile acid binding activity; nuclear receptor activity; and retinoid X receptor binding activity. Predicted to contribute to double-stranded DNA binding activity. Involved in several processes, including lipid homeostasis; negative regulation of cytokine production; and regulation of transcription, DNA-templated. Predicted to localize to the RNA polymerase II transcription factor complex and nuclear euchromatin. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in extrahepatic cholestasis; hepatocellular carcinoma; and progressive familial intrahepatic cholestasis 5. Is expressed in several structures, including 1st branchial arch; central nervous system; heart; sensory organ; and urinary system. Orthologous to human NR1H4 (nuclear receptor subfamily 1 group H member 4); PARTICIPATES IN bile acid transport pathway; INTERACTS WITH (-)-epigallocatechin 3-gallate; 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI957360; bile acid receptor; farnesoid X activated receptor; farnesoid X-activated receptor; farnesol receptor HRR-1; Fxr; HRR1; nuclear receptor subfamily 1 group H member 4; retinoid X receptor-interacting protein 14; RIP14; RXR-interacting protein 14; Rxrip14
Orthologs:
Homo sapiens (human) : NR1H4 (nuclear receptor subfamily 1 group H member 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nr1h4 (nuclear receptor subfamily 1, group H, member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr1h4 (nuclear receptor subfamily 1 group H member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : NR1H4 (nuclear receptor subfamily 1 group H member 4)
Canis lupus familiaris (dog) : NR1H4 (nuclear receptor subfamily 1 group H member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr1h4 (nuclear receptor subfamily 1 group H member 4)
Sus scrofa (pig) : NR1H4 (nuclear receptor subfamily 1 group H member 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381089,454,234 - 89,533,645 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371088,916,979 - 88,996,367 (-)NCBIGRCm37mm9NCBIm37
MGSCv361088,884,177 - 88,936,426 (-)NCBImm8
Celera1091,441,224 - 91,574,747 (-)NCBICelera
Cytogenetic Map10 C2NCBI
cM Map1044.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nr1h4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734104
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.