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Gene: CLCN1 (chloride voltage-gated channel 1) Homo sapiens
Symbol: CLCN1
Name: chloride voltage-gated channel 1
Description: Exhibits protein homodimerization activity and voltage-gated chloride channel activity. Involved in chloride transmembrane transport and muscle contraction. Localizes to the integral component of plasma membrane. Implicated in myotonia congenita.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: chloride channel 1, skeletal muscle; chloride channel protein 1; chloride channel protein, skeletal muscle; chloride channel, voltage-sensitive 1; clC-1; CLC1; MGC138361; MGC142055
Mus musculus (house mouse) : Clcn1 (chloride channel, voltage-sensitive 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Clcn1 (chloride voltage-gated channel 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Clcn1 (chloride voltage-gated channel 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CLCN1 (chloride voltage-gated channel 1)
Canis lupus familiaris (dog) : CLCN1 (chloride voltage-gated channel 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Clcn1 (chloride voltage-gated channel 1)
Sus scrofa (pig) : CLCN1 (chloride voltage-gated channel 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387143,316,111 - 143,352,083 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377143,013,219 - 143,049,097 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367142,723,341 - 142,759,219 (+)NCBINCBI36hg18NCBI36
Build 347142,530,055 - 142,565,934NCBI
Celera7137,850,084 - 137,885,958 (+)NCBI
Cytogenetic Map7q34NCBI
HuRef7137,350,584 - 137,386,478 (+)NCBIHuRef
CHM1_17142,950,106 - 142,986,018 (+)NCBICHM1_1
CRA_TCAGchr7v27142,415,337 - 142,451,223 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CLCN1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734112
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.