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Gene: Runx3 (runt related transcription factor 3) Mus musculus
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Symbol: Runx3
Name: runt related transcription factor 3
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including hair follicle morphogenesis; mRNA transcription by RNA polymerase II; and regulation of alpha-beta T cell differentiation. Localizes to nuclear chromatin. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study asthma and inflammatory bowel disease. Human ortholog(s) of this gene implicated in breast cancer (multiple); female reproductive organ cancer (multiple); in situ carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acute myeloid leukemia 2 protein; AML2; CBF-alpha-3; Cbfa3; core binding factor alpha 3; core-binding factor subunit alpha-3; oncogene AML-2; PEA2-alpha C; PEBP2-alpha C; Pebp2a3; polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; runt-related transcription factor 3; Rx3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2/CBFA3
Orthologs:
Homo sapiens (human) : RUNX3 (RUNX family transcription factor 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Runx3 (RUNX family transcription factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Runx3 (RUNX family transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : RUNX3 (RUNX family transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Runx3 (RUNX family transcription factor 3)
Sus scrofa (pig) : RUNX3 (RUNX family transcription factor 3)
Chlorocebus sabaeus (African green monkey) : RUNX3 (RUNX family transcription factor 3)
Heterocephalus glaber (naked mole-rat) : Runx3 (RUNX family transcription factor 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl4135,120,652 - 135,177,990 (+)EnsemblGRCm38mm10GRCm38
GRCm384135,120,645 - 135,177,990 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374134,676,560 - 134,733,905 (+)NCBIGRCm37mm9NCBIm37
MGSCv364134,392,721 - 134,450,066 (+)NCBImm8
Celera4133,305,992 - 133,363,404 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map467.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Runx3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734144
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.