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Gene: Runx3 (runt related transcription factor 3) Mus musculus
Symbol: Runx3
Name: runt related transcription factor 3
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including hair follicle morphogenesis; mRNA transcription by RNA polymerase II; and regulation of alpha-beta T cell differentiation. Localizes to nuclear chromatin. Is expressed in several structures, including alimentary system; genitourinary system; limb; nervous system; and sensory organ. Used to study asthma and inflammatory bowel disease. Human ortholog(s) of this gene implicated in breast cancer (multiple); female reproductive organ cancer (multiple); in situ carcinoma; pancreatic cancer; and urinary bladder cancer. Orthologous to human RUNX3 (RUNX family transcription factor 3); PARTICIPATES IN transforming growth factor-beta Smad dependent signaling pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: acute myeloid leukemia 2 protein; AML2; CBF-alpha-3; Cbfa3; core binding factor alpha 3; core-binding factor subunit alpha-3; oncogene AML-2; PEA2-alpha C; PEBP2-alpha C; Pebp2a3; polyomavirus enhancer-binding protein 2 alpha C subunit; runt domain, alpha subunit 3; runt-related transcription factor 3; Rx3; SL3-3 enhancer factor 1 alpha C subunit; SL3/AKV core-binding factor alpha C subunit; transcription factor AML2/CBFA3
Homo sapiens (human) : RUNX3 (RUNX family transcription factor 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Runx3 (RUNX family transcription factor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Runx3 (RUNX family transcription factor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : RUNX3 (RUNX family transcription factor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Runx3 (RUNX family transcription factor 3)
Sus scrofa (pig) : RUNX3 (RUNX family transcription factor 3)
Chlorocebus sabaeus (African green monkey) : RUNX3 (RUNX family transcription factor 3)
Heterocephalus glaber (naked mole-rat) : Runx3 (RUNX family transcription factor 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl4135,120,652 - 135,177,990 (+)EnsemblGRCm38mm10GRCm38
GRCm384135,120,645 - 135,177,990 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374134,676,560 - 134,733,905 (+)NCBIGRCm37mm9NCBIm37
MGSCv364134,392,721 - 134,450,066 (+)NCBImm8
Celera4133,305,992 - 133,363,404 (+)NCBICelera
Cytogenetic Map4D3NCBI
cM Map467.19NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Runx3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734144
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.