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Gene: Acvr1 (activin A receptor, type 1) Mus musculus
Symbol: Acvr1
Name: activin A receptor, type 1
Description: Exhibits activin binding activity; transforming growth factor beta binding activity; and transmembrane receptor protein serine/threonine kinase activity. Involved in several processes, including chordate embryonic development; circulatory system development; and gastrulation. Localizes to the apical part of cell and integral component of plasma membrane. Used to study fibrodysplasia ossificans progressiva. Human ortholog(s) of this gene implicated in fibrodysplasia ossificans progressiva. Is expressed in several structures, including alimentary system; brain; embryo mesenchyme; male reproductive gland or organ; and sensory organ. Orthologous to human ACVR1 (activin A receptor type 1); PARTICIPATES IN activin signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activin receptor type I; activin receptor type-1; ActR-I; ActRIA; Acvr; Acvr1a; Acvrlk2; Alk-2; ALK2; Alk8; D330013D15Rik; serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSK-7L; Tsk7L; TSR-I
Homo sapiens (human) : ACVR1 (activin A receptor type 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Acvr1 (activin A receptor type 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Acvr1 (activin A receptor type 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ACVR1 (activin A receptor type 1)
Canis lupus familiaris (dog) : ACVR1 (activin A receptor type 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Acvr1 (activin A receptor type 1)
Sus scrofa (pig) : ACVR1 (activin A receptor type 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38258,446,438 - 58,566,828 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37258,298,849 - 58,419,239 (-)NCBIGRCm37mm9NCBIm37
MGSCv36258,261,824 - 58,331,545 (-)NCBImm8
Celera260,202,316 - 60,294,260 (-)NCBICelera
Cytogenetic Map2 C1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Acvr1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734161
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.