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Gene: CYBA (cytochrome b-245 alpha chain) Homo sapiens
Symbol: CYBA
Name: cytochrome b-245 alpha chain
CRRD ID: 734174
Description: Exhibits SH3 domain binding activity; electron transfer activity; and protein heterodimerization activity. Contributes to superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of toll-like receptor 2 signaling pathway; and superoxide anion generation. Localizes to NADPH oxidase complex. Implicated in artery disease (multiple); asthma; chronic obstructive pulmonary disease; and phagocyte bactericidal dysfunction (multiple). Biomarker of acute lymphoblastic leukemia and obstructive sleep apnea.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CGD4; cytochrome b light chain; cytochrome b(558) alpha chain; cytochrome b(558) alpha-subunit; cytochrome b, alpha polypeptide; cytochrome b-245 light chain; cytochrome b-245, alpha polypeptide; cytochrome b558 alpha-subunit; cytochrome b558 subunit alpha; flavocytochrome b-558 alpha polypeptide; FLJ43590; FLJ99071; neutrophil cytochrome b 22 kDa polypeptide; p22 phagocyte B-cytochrome; p22-PHOX; p22phox; superoxide-generating NADPH oxidase light chain subunit
Mus musculus (house mouse) : Cyba (cytochrome b-245, alpha polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyba (cytochrome b-245 alpha chain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102004641 (cytochrome b-245 light chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100986914 (cytochrome b-245 light chain)
Canis lupus familiaris (dog) : CYBA (cytochrome b-245 alpha chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101967032 (cytochrome b-245 light chain)
Sus scrofa (pig) : CYBA (cytochrome b-245 alpha chain)
Chlorocebus sabaeus (African green monkey) : LOC103233451 (cytochrome b-245 light chain)
Heterocephalus glaber (naked mole-rat) : LOC101717043 (cytochrome b-245 light chain)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1688,643,289 - 88,651,054 (-)EnsemblGRCh38hg38GRCh38
GRCh381688,643,289 - 88,651,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371688,709,697 - 88,717,492 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361687,237,198 - 87,244,958 (-)NCBINCBI36hg18NCBI36
Build 341687,237,198 - 87,244,950NCBI
Celera1673,779,369 - 73,787,129 (-)NCBI
Cytogenetic Map16q24.2NCBI
HuRef1674,403,728 - 74,411,523 (-)NCBIHuRef
CHM1_11690,120,999 - 90,128,842 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CYBA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734174
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.