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Gene: PFN2 (profilin 2) Homo sapiens
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Symbol: PFN2
Name: profilin 2
Description: Exhibits ATPase activity; actin monomer binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including negative regulation of ruffle assembly; protein stabilization; and regulation of actin filament organization. Localizes to the extracellular exosome.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D3S1319E; PFL; profilin II; profilin-2
Orthologs:
Mus musculus (house mouse) : Pfn2 (profilin 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pfn2 (profilin 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pfn2 (profilin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PFN2 (profilin 2)
Canis lupus familiaris (dog) : PFN2 (profilin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pfn2 (profilin 2)
Sus scrofa (pig) : PFN2 (profilin 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl3149,964,904 - 150,050,788 (-)Ensembl
GRCh383149,964,904 - 149,970,895 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373149,682,691 - 149,688,741 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363151,165,381 - 151,171,431 (-)NCBINCBI36hg18NCBI36
Build 343151,165,391 - 151,171,355NCBI
Celera3148,096,052 - 148,102,101 (-)NCBI
Cytogenetic Map3q25.1NCBI
HuRef3147,055,266 - 147,061,316 (-)NCBIHuRef
CHM1_13149,645,850 - 149,651,900 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PFN2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734176
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.