Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Flt1 (FMS-like tyrosine kinase 1) Mus musculus
Symbol: Flt1
Name: FMS-like tyrosine kinase 1
CRRD ID: 734184
Description: Exhibits identical protein binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Localizes to extracellular space and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1); PARTICIPATES IN axitinib pharmacodynamics pathway; bevacizumab pharmacodynamics pathway; glypican signaling pathway; INTERACTS WITH (R)-lipoic acid; 1,1-dichloroethene; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI323757; embryonic receptor kinase 2; Flt-; Flt-1; sFl; sFlt1; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; vascular permeability factor receptor; VEGF; VEGFR; VEGFR-1; VEGFR1
Homo sapiens (human) : FLT1 (fms related receptor tyrosine kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flt1 (Fms related receptor tyrosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt1 (fms related receptor tyrosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT1 (fms related receptor tyrosine kinase 1)
Canis lupus familiaris (dog) : FLT1 (fms related receptor tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt1 (fms related receptor tyrosine kinase 1)
Sus scrofa (pig) : FLT1 (fms related receptor tyrosine kinase 1)
Chlorocebus sabaeus (African green monkey) : FLT1 (fms related receptor tyrosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Flt1 (fms related receptor tyrosine kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5147,561,604 - 147,726,011 (-)EnsemblGRCm38mm10GRCm38
GRCm385147,561,604 - 147,726,438 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375148,373,772 - 148,537,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv365147,872,545 - 148,036,337 (-)NCBImm8
Celera5145,555,589 - 145,721,706 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map587.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Flt1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734184
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.