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Gene: Flt1 (FMS-like tyrosine kinase 1) Mus musculus
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Symbol: Flt1
Name: FMS-like tyrosine kinase 1
CRRD ID: 734184
Description: Exhibits identical protein binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Localizes to extracellular space and nucleus. Is expressed in several structures, including alimentary system; brain; cardiovascular system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1); PARTICIPATES IN axitinib pharmacodynamics pathway; bevacizumab pharmacodynamics pathway; glypican signaling pathway; INTERACTS WITH (R)-lipoic acid; 1,1-dichloroethene; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI323757; embryonic receptor kinase 2; Flt-; Flt-1; sFl; sFlt1; tyrosine-protein kinase receptor FLT; vascular endothelial growth factor receptor 1; vascular endothelial growth factor receptor-1; vascular permeability factor receptor; VEGF; VEGFR; VEGFR-1; VEGFR1
Orthologs:
Homo sapiens (human) : FLT1 (fms related receptor tyrosine kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Flt1 (Fms related receptor tyrosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Flt1 (fms related receptor tyrosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FLT1 (fms related receptor tyrosine kinase 1)
Canis lupus familiaris (dog) : FLT1 (fms related receptor tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Flt1 (fms related receptor tyrosine kinase 1)
Sus scrofa (pig) : FLT1 (fms related receptor tyrosine kinase 1)
Chlorocebus sabaeus (African green monkey) : FLT1 (fms related receptor tyrosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Flt1 (fms related receptor tyrosine kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl5147,561,604 - 147,726,011 (-)EnsemblGRCm38mm10GRCm38
GRCm385147,561,604 - 147,726,438 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375148,373,772 - 148,537,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv365147,872,545 - 148,036,337 (-)NCBImm8
Celera5145,555,589 - 145,721,706 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map587.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Flt1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734184
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.