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Gene: GPT (glutamic--pyruvic transaminase) Homo sapiens
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Symbol: GPT
Name: glutamic--pyruvic transaminase
Description: This gene encodes cytosolic alanine aminotransaminase 1 (ALT1); also known as glutamate-pyruvate transaminase 1. This enzyme catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate and, therefore, plays a key role in the intermediary metabolism of glucose and amino acids. Serum activity levels of this enzyme are routinely used as a biomarker of liver injury caused by drug toxicity, infection, alcohol, and steatosis. A related gene on chromosome 16 encodes a putative mitochondrial alanine aminotransaminase.[provided by RefSeq, Nov 2009]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT1; alanine aminotransferase; alanine aminotransferase 1; alanine transaminase; ALT1; glutamate pyruvate transaminase 1; glutamic--alanine transaminase 1; glutamic--pyruvic transaminase 1; glutamic-alanine transaminase 1; glutamic-pyruvate transaminase (alanine aminotransferase); GPT 1; GPT1
Orthologs:
Mus musculus (house mouse) : Gpt (glutamic pyruvic transaminase, soluble)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gpt (glutamic--pyruvic transaminase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gpt (glutamic--pyruvic transaminase)
Pan paniscus (bonobo/pygmy chimpanzee) : GPT (glutamic--pyruvic transaminase)
Canis lupus familiaris (dog) : GPT (glutamic--pyruvic transaminase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gpt (glutamic--pyruvic transaminase)
Sus scrofa (pig) : GPT (glutamic--pyruvic transaminase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh388144,502,217 - 144,507,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh378145,729,465 - 145,732,555 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 368145,700,231 - 145,703,357 (+)NCBINCBI36hg18NCBI36
Build 348145,700,232 - 145,703,357NCBI
Celera8141,904,937 - 141,908,027 (+)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8140,842,619 - 140,845,709 (+)NCBIHuRef
CHM1_18145,767,740 - 145,770,746 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on GPT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734191
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-02
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.