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Gene: TANK (TRAF family member associated NFKB activator) Homo sapiens
Symbol: TANK
Name: TRAF family member associated NFKB activator
Description: Exhibits deubiquitinase activator activity and ubiquitin protein ligase binding activity. Contributes to thiol-dependent ubiquitin-specific protease activity. Involved in several processes, including cellular response to cytokine stimulus; negative regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of proteolysis. Localizes to the cytosol and protein-containing complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: I-TRAF; ITRAF; traf family member-associated nf-kappa b activator; TRAF family member-associated NF-kappa-B activator; TRAF family member-associated NFKB activator; TRAF-interacting protein; TRAF2
Mus musculus (house mouse) : Tank (TRAF family member-associated Nf-kappa B activator)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tank (TRAF family member-associated NFKB activator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tank (TRAF family member associated NFKB activator)
Pan paniscus (bonobo/pygmy chimpanzee) : TANK (TRAF family member associated NFKB activator)
Canis lupus familiaris (dog) : TANK (TRAF family member associated NFKB activator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tank (TRAF family member associated NFKB activator)
Sus scrofa (pig) : TANK (TRAF family member associated NFKB activator)
Chlorocebus sabaeus (African green monkey) : TANK (TRAF family member associated NFKB activator)
Heterocephalus glaber (naked mole-rat) : Tank (TRAF family member associated NFKB activator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl2161,136,908 - 161,236,230 (+)EnsemblGRCh38hg38GRCh38
GRCh382161,136,955 - 161,236,230 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372161,993,438 - 162,092,687 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362161,701,712 - 161,800,928 (+)NCBINCBI36hg18NCBI36
Build 342161,818,972 - 161,886,997NCBI
Celera2155,605,253 - 155,704,471 (+)NCBI
Cytogenetic Map2q24.2NCBI
HuRef2153,878,179 - 153,977,180 (+)NCBIHuRef
CHM1_12161,999,604 - 162,098,821 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TANK
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734196
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.