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Gene: MIF (macrophage migration inhibitory factor) Homo sapiens
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Symbol: MIF
Name: macrophage migration inhibitory factor
Description: Exhibits several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Localizes to several cellular components, including the cell surface; extracellular space; and nucleoplasm. Implicated in allergic hypersensitivity disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Biomarker of artery disease (multiple); asthma; lung disease (multiple); obesity; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GIF; GLIF; L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MMIF; phenylpyruvate tautomerase
Orthologs:
Mus musculus (house mouse) : Mif (macrophage migration inhibitory factor (glycosylation-inhibiting factor))  MGI  Alliance
Rattus norvegicus (Norway rat) : Mif (macrophage migration inhibitory factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mif (macrophage migration inhibitory factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MIF (macrophage migration inhibitory factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mif (macrophage migration inhibitory factor)
Sus scrofa (pig) : MIF (macrophage migration inhibitory factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,894,383 - 23,895,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,236,565 - 24,237,409 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,566,565 - 22,567,409 (+)NCBINCBI36hg18NCBI36
Build 342222,561,118 - 22,561,963NCBI
Celera228,074,325 - 8,075,169 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,221,904 - 7,222,748 (+)NCBIHuRef
CHM1_12224,248,957 - 24,249,801 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on MIF
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734203
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.