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Gene: MIF (macrophage migration inhibitory factor) Homo sapiens
Symbol: MIF
Name: macrophage migration inhibitory factor
Description: Exhibits several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of cell population proliferation; positive regulation of protein phosphorylation; and regulation of intracellular signal transduction. Localizes to several cellular components, including the cell surface; extracellular space; and nucleoplasm. Implicated in allergic hypersensitivity disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Biomarker of artery disease (multiple); asthma; lung disease (multiple); obesity; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: GIF; GLIF; L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MMIF; phenylpyruvate tautomerase
Mus musculus (house mouse) : Mif (macrophage migration inhibitory factor (glycosylation-inhibiting factor))  MGI  Alliance
Rattus norvegicus (Norway rat) : Mif (macrophage migration inhibitory factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mif (macrophage migration inhibitory factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MIF (macrophage migration inhibitory factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mif (macrophage migration inhibitory factor)
Sus scrofa (pig) : MIF (macrophage migration inhibitory factor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh382223,894,383 - 23,895,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,236,565 - 24,237,409 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,566,565 - 22,567,409 (+)NCBINCBI36hg18NCBI36
Build 342222,561,118 - 22,561,963NCBI
Celera228,074,325 - 8,075,169 (+)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,221,904 - 7,222,748 (+)NCBIHuRef
CHM1_12224,248,957 - 24,249,801 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on MIF
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734203
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.