Gene: SST (somatostatin) Homo sapiens
Analyze
Symbol:
SST
Name:
somatostatin
Description:
Predicted to have hormone activity. Predicted to be involved in regulation of cell migration. Predicted to localize to the extracellular space.
Type:
protein-coding
RefSeq Status:
REVIEWED
Also known as:
growth hormone release-inhibiting factor; prepro-somatostatin; SMST; somatostatin-14; somatostatin-28
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
Sst (somatostatin) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Sst (somatostatin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Pan paniscus (bonobo/pygmy chimpanzee):
SST (somatostatin) NCBI
Ortholog
Canis lupus familiaris (dog):
SST (somatostatin) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Sst (somatostatin) NCBI
Ortholog
Sus scrofa (pig):
SST (somatostatin) HGNC
Ensembl, Inparanoid, NCBI, OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Sst (somatostatin)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Sst (somatostatin)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
sst1.2 (somatostatin 1, tandem duplicate 2)
Alliance
DIOPT (PANTHER, TreeFam, ZFIN)
Danio rerio (zebrafish):
sst1.1 (somatostatin 1, tandem duplicate 1)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB, TreeFam, ZFIN)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 3 187,668,912 - 187,670,394 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 3 187,386,694 - 187,388,201 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 3 188,869,388 - 188,870,895 (-) NCBI NCBI36 hg18 NCBI36 Build 34 3 188,869,406 - 188,870,808 NCBI Celera 3 185,817,667 - 185,819,174 (-) NCBI Cytogenetic Map 3 q27.3 NCBI HuRef 3 184,791,007 - 184,792,514 (-) NCBI HuRef CHM1_1 3 187,349,954 - 187,351,461 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
schizophrenia IAGP RGD:14351925 8554872 ClinVar Annotator: match by term: Schizophrenia ClinVar PMID:21681106 , PMID:30208311
Imported Annotations - CTD
Barrett's esophagus EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17999418 disease of cellular proliferation EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:21692635 endometriosis EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21063030 Esophageal Neoplasms EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17999418 esophageal varix EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:1385068 hypokalemia EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:2563217 ischemia EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:18624922 mood disorder EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25600109 Multiple Organ Failure EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:15834315 pancreatic cancer EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:2868874 pancreatitis EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:7911442 Spontaneous Abortions EXP 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18539642 vipoma EXP 11554173 CTD Direct Evidence: therapeutic CTD PMID:2868874 visual epilepsy EXP 11554173 CTD Direct Evidence: marker/mechanism, therapeutic CTD PMID:7913897 more ...
(S)-nicotine decreases expression ISO RGD:737256 6480464 Nicotine results in decreased expression of SST mRNA CTD PMID:17997037 17alpha-ethynylestradiol multiple interactions ISO RGD:737256 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SST mRNA CTD PMID:17942748 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO RGD:3761 6480464 [2 more ... CTD PMID:19327374 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:737256 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SST mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:737256 6480464 Tetrachlorodibenzodioxin results in increased expression of SST mRNA CTD PMID:16922920 2-acetamidofluorene increases expression ISO RGD:3761 6480464 2-Acetylaminofluorene results in increased expression of SST protein CTD PMID:16534498 3',5'-cyclic AMP multiple interactions EXP 6480464 [SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] CTD PMID:22056254 3,3',4,4',5-pentachlorobiphenyl multiple interactions ISO RGD:3761 6480464 [2 more ... CTD PMID:19327374 5-aza-2'-deoxycytidine affects methylation EXP 6480464 Decitabine affects the methylation of SST promoter CTD PMID:17999418 5-fluorouracil increases expression ISO RGD:737256 6480464 Fluorouracil results in increased expression of SST protein CTD PMID:21296659 6-propyl-2-thiouracil increases expression ISO RGD:3761 6480464 Propylthiouracil results in increased expression of SST mRNA CTD PMID:24780913 acetic acid decreases expression ISO RGD:737256 6480464 Acetic Acid results in decreased expression of SST protein CTD PMID:21296659 aflatoxin B1 decreases methylation EXP 6480464 Aflatoxin B1 results in decreased methylation of SST gene CTD PMID:27153756 all-trans-retinoic acid increases expression EXP 6480464 Tretinoin results in increased expression of SST mRNA, Tretinoin results in increased expression of SST protein CTD PMID:16473924 , PMID:21934132 all-trans-retinol multiple interactions ISO RGD:737256 6480464 [Vitamin A co-treated with INHBA protein] results in increased expression of SST mRNA CTD PMID:17244017 all-trans-retinol affects expression ISO RGD:3761 6480464 Vitamin A affects the expression of SST protein CTD PMID:16757122 ammonium chloride affects expression ISO RGD:3761 6480464 Ammonium Chloride affects the expression of SST mRNA CTD PMID:16483693 arsenite(3-) increases methylation EXP 6480464 arsenite results in increased methylation of SST promoter CTD PMID:23974009 belinostat increases expression EXP 6480464 belinostat results in increased expression of SST mRNA CTD PMID:26272509 benzo[a]pyrene decreases expression ISO RGD:737256 6480464 Benzo(a)pyrene results in decreased expression of SST mRNA CTD PMID:27195522 bethanechol affects secretion ISO RGD:3761 6480464 Bethanechol affects the secretion of SST protein CTD PMID:19296048 bethanechol multiple interactions ISO RGD:3761 6480464 CALCA protein promotes the reaction [Bethanechol affects the secretion of SST protein] CTD PMID:19296048 bisphenol A multiple interactions ISO RGD:3761 6480464 bisphenol A promotes the reaction [SST binds to SSTR2 protein alternative form] more ... CTD PMID:12060835 bisphenol A decreases expression ISO RGD:3761 6480464 bisphenol A results in decreased expression of SST mRNA CTD PMID:25181051 bromochloroacetic acid increases expression ISO RGD:737256 6480464 bromochloroacetic acid results in increased expression of SST protein CTD PMID:21296659 capsaicin decreases expression ISO RGD:3761 6480464 Capsaicin results in decreased expression of SST mRNA CTD PMID:8093704 capsaicin increases secretion ISO RGD:3761 6480464 Capsaicin results in increased secretion of SST protein CTD PMID:19296048 more ... capsaicin increases expression ISO RGD:3761 6480464 Capsaicin results in increased expression of SST protein CTD PMID:16938409 capsaicin multiple interactions ISO RGD:3761 6480464 AMN protein inhibits the reaction [Capsaicin results in increased expression of SST protein] CTD PMID:16938409 capsaicin increases expression ISO RGD:737256 6480464 Capsaicin results in increased expression of SST protein CTD PMID:19878665 carbamazepine affects expression EXP 6480464 Carbamazepine affects the expression of SST mRNA CTD PMID:25979313 chlorpyrifos decreases expression ISO RGD:3761 6480464 Chlorpyrifos results in decreased expression of SST mRNA CTD PMID:20682304 Citreoviridin increases expression ISO RGD:737256 6480464 citreoviridin results in increased expression of SST mRNA CTD PMID:30071239 clozapine multiple interactions ISO RGD:3761 6480464 Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST mRNA], Clozapine inhibits the reaction [Dizocilpine Maleate results in decreased expression of SST protein] CTD PMID:16567023 Colforsin dapropate hydrochloride multiple interactions EXP 6480464 [SST protein co-treated with SSTR2 protein] inhibits the reaction [Colforsin results in increased chemical synthesis of Cyclic AMP] CTD PMID:22056254 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of SST mRNA CTD PMID:19549813 cysteamine decreases expression ISO RGD:3761 6480464 Cysteamine results in decreased expression of SST protein CTD PMID:15778430 DDE multiple interactions ISO RGD:3761 6480464 Dichlorodiphenyl Dichloroethylene inhibits the reaction [Dietary Fats results in increased expression of SST mRNA] CTD PMID:28572628 DDT decreases expression ISO RGD:3761 6480464 DDT results in decreased expression of SST mRNA CTD PMID:19797855 dexamethasone decreases expression EXP 6480464 Dexamethasone results in decreased expression of SST mRNA CTD PMID:25047013 dichlorine multiple interactions ISO RGD:3761 6480464 [Ozone co-treated with Chlorine] results in increased expression of SST mRNA CTD PMID:18636392 dorsomorphin multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 ethanol affects expression ISO RGD:737256 6480464 Ethanol affects the expression of SST mRNA CTD PMID:30319688 fonofos increases methylation EXP 6480464 Fonofos results in increased methylation of SST promoter CTD PMID:22847954 furan increases expression ISO RGD:3761 6480464 furan results in increased expression of SST mRNA CTD PMID:27387713 gentamycin decreases response to substance ISO RGD:3761 6480464 SST protein results in decreased susceptibility to Gentamicins CTD PMID:19294753 histamine multiple interactions ISO RGD:3761 6480464 SST protein inhibits the reaction [ADCYAP1 protein results in increased secretion of Histamine], SST protein inhibits the reaction [GAST protein results in increased secretion of Histamine] CTD PMID:11164953 hydrogen chloride increases expression ISO RGD:3761 6480464 Hydrochloric Acid results in increased expression of SST protein CTD PMID:9530148 hydrogen peroxide decreases expression EXP 6480464 Hydrogen Peroxide results in decreased expression of SST mRNA CTD PMID:12414654 kainic acid decreases expression ISO RGD:737256 6480464 Kainic Acid results in decreased expression of SST mRNA CTD PMID:17997037 L-ascorbic acid increases expression ISO RGD:3761 6480464 Ascorbic Acid results in increased expression of SST mRNA CTD PMID:15372504 Lafutidine increases expression EXP 6480464 lafutidine results in increased expression of SST protein CTD PMID:16416222 lipopolysaccharide increases expression ISO RGD:737256 6480464 Lipopolysaccharides results in increased expression of SST protein CTD PMID:17291600 lipopolysaccharide multiple interactions ISO RGD:737256 6480464 resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SST protein] CTD PMID:17291600 menadione decreases expression EXP 6480464 Vitamin K 3 results in decreased expression of SST mRNA CTD PMID:12414654 mercury dibromide increases expression EXP 6480464 mercuric bromide results in increased expression of SST mRNA CTD PMID:26272509 mercury dibromide multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA CTD PMID:27188386 metformin increases expression ISO RGD:737256 6480464 Metformin results in increased expression of SST mRNA CTD PMID:23457588 methylmercury chloride increases expression EXP 6480464 methylmercuric chloride results in increased expression of SST mRNA CTD PMID:28001369 morphine increases expression ISO RGD:737256 6480464 Morphine results in increased expression of SST mRNA CTD PMID:21178816 N-methyl-4-phenylpyridinium decreases expression EXP 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of SST mRNA CTD PMID:24810058 nicotine decreases expression ISO RGD:737256 6480464 Nicotine results in decreased expression of SST mRNA CTD PMID:17997037 octreotide decreases secretion EXP 6480464 Octreotide results in decreased secretion of SST protein CTD PMID:16601281 ozone multiple interactions ISO RGD:3761 6480464 [Ozone co-treated with Chlorine] results in increased expression of SST mRNA CTD PMID:18636392 p-chloromercuribenzoic acid multiple interactions EXP 6480464 [NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA CTD PMID:27188386 panobinostat multiple interactions EXP 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA CTD PMID:27188386 panobinostat increases expression EXP 6480464 panobinostat results in increased expression of SST mRNA CTD PMID:26272509 paracetamol affects expression ISO RGD:737256 6480464 Acetaminophen affects the expression of SST mRNA CTD PMID:17562736 paraquat affects expression ISO RGD:3761 6480464 Paraquat affects the expression of SST mRNA CTD PMID:15206577 parathion increases methylation EXP 6480464 Parathion results in increased methylation of SST promoter CTD PMID:22847954 phenylmercury acetate multiple interactions EXP 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of SST mRNA CTD PMID:27188386 pirinixic acid decreases expression ISO RGD:737256 6480464 pirinixic acid results in decreased expression of SST mRNA CTD PMID:17426115 potassium atom increases secretion EXP 6480464 Potassium results in increased secretion of SST protein CTD PMID:16601281 progesterone decreases expression EXP 6480464 Progesterone results in decreased expression of SST mRNA CTD PMID:17404688 progesterone increases expression ISO RGD:3761 6480464 Progesterone results in increased expression of SST mRNA CTD PMID:16376865 Resiniferatoxin multiple interactions ISO RGD:737256 6480464 resiniferatoxin inhibits the reaction [Lipopolysaccharides results in increased expression of SST protein] CTD PMID:17291600 SB 431542 multiple interactions EXP 6480464 [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 tamoxifen multiple interactions ISO RGD:3761 6480464 Tamoxifen promotes the reaction [SST protein results in decreased secretion of GH1 protein] CTD PMID:1350760 terbufos increases methylation EXP 6480464 terbufos results in increased methylation of SST promoter CTD PMID:22847954 terbutaline multiple interactions EXP 6480464 SST inhibits the reaction [Terbutaline results in increased expression of INS protein] CTD PMID:2563217 tert-butyl hydroperoxide decreases expression EXP 6480464 tert-Butylhydroperoxide results in decreased expression of SST mRNA CTD PMID:12414654 tetrachloromethane increases expression ISO RGD:3761 6480464 Carbon Tetrachloride results in increased expression of SST mRNA CTD PMID:17805973 theophylline increases secretion EXP 6480464 Theophylline results in increased secretion of SST protein CTD PMID:16601281 trichostatin A increases expression EXP 6480464 trichostatin A results in increased expression of SST mRNA CTD PMID:24935251 triclosan decreases expression EXP 6480464 Triclosan results in decreased expression of SST mRNA CTD PMID:30510588 Tryptanthrine increases expression EXP 6480464 tryptanthrine results in increased expression of SST mRNA CTD PMID:23500671 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of SST mRNA CTD PMID:23179753 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of SST mRNA CTD PMID:25979313 vinclozolin affects expression ISO RGD:3761 6480464 vinclozolin affects the expression of SST mRNA CTD PMID:19015723 zinc atom decreases expression EXP 6480464 Zinc deficiency results in decreased expression of SST mRNA CTD PMID:18356318 zinc atom decreases secretion ISO RGD:3761 6480464 Zinc deficiency results in decreased secretion of SST protein CTD PMID:11842894 zinc atom increases expression ISO RGD:3761 6480464 Zinc deficiency results in increased expression of SST mRNA CTD PMID:11717422 zinc(0) decreases expression EXP 6480464 Zinc deficiency results in decreased expression of SST mRNA CTD PMID:18356318 zinc(0) decreases secretion ISO RGD:3761 6480464 Zinc deficiency results in decreased secretion of SST protein CTD PMID:11842894 zinc(0) increases expression ISO RGD:3761 6480464 Zinc deficiency results in increased expression of SST mRNA CTD PMID:11717422 zolpidem multiple interactions ISO RGD:3761 6480464 zolpidem promotes the reaction [bisphenol A promotes the reaction [SST binds to SSTR2 protein alternative form]], zolpidem promotes the reaction [SST binds to SSTR2 protein alternative form] CTD PMID:12060835
Gene-Chemical Interaction Annotations
