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Gene: NTRK1 (neurotrophic receptor tyrosine kinase 1) Homo sapiens
Symbol: NTRK1
Name: neurotrophic receptor tyrosine kinase 1
CRRD ID: 734274
Description: Exhibits several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and protein homodimerization activity. Involved in several processes, including generation of neurons; neurotrophin signaling pathway; and positive regulation of intracellular signal transduction. Localizes to integral component of plasma membrane and receptor complex. Implicated in Alzheimer's disease; hereditary sensory neuropathy; hereditary sensory neuropathy type 4; and schizophrenia. Biomarker of several diseases, including Hirschsprung's disease; lung disease (multiple); neuroblastoma; obstructive sleep apnea; and rhinitis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781I14186; gp140trk; high affinity nerve growth factor receptor; MTC; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; TRK; trk precursor; Trk-A; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; tropomyosin-related kinase A; tyrosine kinase receptor A
Mus musculus (house mouse) : Ntrk1 (neurotrophic tyrosine kinase, receptor, type 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
Canis lupus familiaris (dog) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
Sus scrofa (pig) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Chlorocebus sabaeus (African green monkey) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1156,815,640 - 156,881,850 (+)EnsemblGRCh38hg38GRCh38
GRCh381156,815,750 - 156,881,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371156,785,542 - 156,851,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,052,166 - 155,118,266 (+)NCBINCBI36hg18NCBI36
Build 341153,643,743 - 153,664,715NCBI
Celera1129,856,788 - 129,922,861 (+)NCBI
Cytogenetic Map1q23.1NCBI
HuRef1128,143,945 - 128,209,968 (+)NCBIHuRef
CHM1_11158,181,737 - 158,247,825 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NTRK1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734274
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.