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Gene: NTRK1 (neurotrophic receptor tyrosine kinase 1) Homo sapiens
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Symbol: NTRK1
Name: neurotrophic receptor tyrosine kinase 1
Description: This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DKFZp781I14186; gp140trk; high affinity nerve growth factor receptor; MTC; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; TRK; trk precursor; Trk-A; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; tropomyosin-related kinase A; tyrosine kinase receptor A
Orthologs:
Mus musculus (house mouse) : Ntrk1 (neurotrophic tyrosine kinase, receptor, type 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Canis lupus familiaris (dog) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ntrk1 (neurotrophic receptor tyrosine kinase 1)
Sus scrofa (pig) : NTRK1 (neurotrophic receptor tyrosine kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,815,750 - 156,881,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371156,785,542 - 156,851,642 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361155,052,166 - 155,118,266 (+)NCBINCBI36hg18NCBI36
Build 341153,643,743 - 153,664,715NCBI
Celera1129,856,788 - 129,922,861 (+)NCBI
Cytogenetic Map1q23.1NCBI
HuRef1128,143,945 - 128,209,968 (+)NCBIHuRef
CHM1_11158,181,737 - 158,247,825 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on NTRK1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 734274
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.